ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >AP26113
AP26113
![AP26113 Structure](CAS/20150408/GIF/1197958-12-5.gif)
- CAS No.
- 1197958-12-5
- Chemical Name:
- AP26113
- Synonyms
- CS-692;AP26113;CS-2153;ALK-IN-1;ASP26113;AP26113-ANALOG;AP26113/AP-26113;Brigatinib-analog;AP26113 USP/EP/BP;Targeted Cancer Therapy
- CBNumber:
- CB12642542
- Molecular Formula:
- C26H34ClN6O2P
- Molecular Weight:
- 529.01
- MOL File:
- 1197958-12-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
Boiling point | 737.6±70.0 °C(Predicted) |
---|---|
Density | 1.29±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH |
form | solid |
pka | 9.27±0.20(Predicted) |
color | White to off-white |
CAS DataBase Reference | 1197958-12-5 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
AP26113 Chemical Properties,Uses,Production
Enzyme inhibitor
This potent ALK inhibitor (FW = 529.02 g/mol; CAS 1197958-12-5; Solubility: 45 mg/mL DMSO; <1 mg/mL H2O), also named 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethyl- phosphinyl)phenyl]-2,4-pyrimidinediamine, inhibits wild type Lymphoma Kinase, or ALK (Ki = 0.62 nM) and overcomes crizotinib resistance in non- small cell lung cancers harboring the fusion oncogene EML4-ALK. Cells often develop the L1196M gatekeeper mutation within the kinase domain, a changes that renders them resistant to crizotinib, even at higher drug doses (1 μM). AP26113 is highly active against these resistant cancer cells, both in vitro and in vivo.
AP26113 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 253)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | China | 294 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18648 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | China | 302 | 58 | Inquiry |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | China | 9807 | 58 | Inquiry |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7121 | 58 | Inquiry |
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1197958-12-5(AP26113)Related Search:
5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
AP26113-ANALOG
(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)ami
AP26113
AP26113/AP-26113
5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine
5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine
5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl]
2,4-Pyrimidinediamine, 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-
5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine AP26113
ALK-IN-1
ASP26113
CS-2153
AP-26113; AP26113; AP 26113;BRIGATINIB
CS-692
AP26113-analog (ALK-IN-1)
ALK-IN-1 (Brigatinib analog, AP26113 analog)
(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Brigatinib-analog
Targeted Cancer Therapy
Antitumor Pharmaceutical Material
Ap26113/Ap-26113/Alk-in-1
AP26113 USP/EP/BP
ALK-IN-1 (Brigatinib analog)
AP26113/ 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
5-chloro-N2-{4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine
low price 1197958-12-5 AP26113
1197958-12-5
197958-12-5
C26H34ClN6O2P
Inhibitors
API