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AP26113

CAS No.: 1197958-12-5

Chemical Name:: AP26113

Synonyms: CS-692;AP26113;CS-2153;ALK-IN-1;ASP26113;AP26113-ANALOG;AP26113/AP-26113;Brigatinib-analog;AP26113 USP/EP/BP;Targeted Cancer Therapy

CBNumber:: CB12642542

Molecular Formula:: C26H34ClN6O2P

Molecular Weight:: 529.01

MOL File:: 1197958-12-5.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:00

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AP26113 Properties

Boiling point	737.6±70.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥26.45 mg/mL in DMSO; insoluble in H2O; ≥55.9 mg/mL in EtOH
form	solid
pka	9.27±0.20(Predicted)
color	White to off-white
CAS DataBase Reference	1197958-12-5

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

AP26113 Chemical Properties,Uses,Production

Enzyme inhibitor

This potent ALK inhibitor (FW = 529.02 g/mol; CAS 1197958-12-5; Solubility: 45 mg/mL DMSO; <1 mg/mL H2O), also named 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethyl- phosphinyl)phenyl]-2,4-pyrimidinediamine, inhibits wild type Lymphoma Kinase, or ALK (Ki = 0.62 nM) and overcomes crizotinib resistance in non- small cell lung cancers harboring the fusion oncogene EML4-ALK. Cells often develop the L1196M gatekeeper mutation within the kinase domain, a changes that renders them resistant to crizotinib, even at higher drug doses (1 μM). AP26113 is highly active against these resistant cancer cells, both in vitro and in vivo.

AP26113 Preparation Products And Raw materials

Raw materials

Preparation Products

AP26113 Suppliers

Global( 253)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177; +8617531190177	China	5873	58	Inquiry
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	China	294	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18648	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	China	302	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	China	9807	58	Inquiry
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	China	7121	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Hebei Yanxi Chemical Co., Ltd.	58
shandong perfect biotechnology co.ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
ENBRIDGE PHARMTECH CO., LTD.	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Shanghai UCHEM Inc.	58

AP26113- Pharmacodynamics
Brigatinib (AP26113) is a tyrosine kinase inhibitor with in vitro activity against a number of kinases, including ALK, ROS1, i....
Dec 13，2019

AP26113 as inhibitor of cancer biomarkers
AP26113, or Brigatinib, is a novel, synthetic, orally active and potent small-molecule inhibitor of anaplastic lymphoma kinase....
Oct 10，2019

AP26113 Spectrum

AP26113(1197958-12-5)¹HNMR

1197958-12-5(AP26113)Related Search:

Lenvatinib Afatinib (BIBW 2992) Vandetanib Ceritinib N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Alectinib ALK/IGF1R inhibitor Crizotinib NVP-TAE684 Lorlatinib (PF-06463922)

BKM-120 Capmatinib Selumetinib Cabozantinib WZ4002

Dabrafenib Dacomitinib (PF299804) 1110813-31-4

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5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine AP26113-ANALOG (2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)ami AP26113 AP26113/AP-26113 5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine 5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine 5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl] 2,4-Pyrimidinediamine, 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]- 5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine AP26113 ALK-IN-1 ASP26113 CS-2153 AP-26113; AP26113; AP 26113;BRIGATINIB CS-692 AP26113-analog (ALK-IN-1) ALK-IN-1 (Brigatinib analog, AP26113 analog) (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide Brigatinib-analog Targeted Cancer Therapy Antitumor Pharmaceutical Material Ap26113/Ap-26113/Alk-in-1 AP26113 USP/EP/BP ALK-IN-1 (Brigatinib analog) AP26113/ 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine 5-chloro-N2-{4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine low price 1197958-12-5 AP26113 1197958-12-5 197958-12-5 C26H34ClN6O2P Inhibitors API