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Capmatinib

CAS No.: 1029712-80-8

Chemical Name:: Capmatinib

Synonyms: INC280;INCB28060;INC28060;2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide;NC280;CS-192;INCB028060;NVP-INC280;CapMatinib;Karma for,

CBNumber:: CB92574678

Molecular Formula:: C23H17FN6O

Molecular Weight:: 412.42

MOL File:: 1029712-80-8.mol

MSDS File:: SDS

Modify Date:: 2024/5/23 14:28:10

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Capmatinib Properties

Melting point	>250°C (dec.)
Density	1.40
vapor pressure	0-0Pa at 20-25℃
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.82±0.46(Predicted)
form	Solid
color	Pale Yellow to Light Yellow
InChI	InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey	LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES	C(NC)(=O)C1=CC=C(C2=NN3C(CC4=CC=C5C(=C4)C=CC=N5)=CN=C3N=C2)C=C1F
LogP	1.6-2.2 at 35℃ and pH7-9

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Capmatinib Chemical Properties,Uses,Production

Description

Capmatinib is a competitive inhibitor with very potent and selective activity against MET compared to other kinases.

Uses

2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide is used in the preparation of a combination formulation with allosteric SHP2 inhibitor TNO155. Used in treatment of non-small cell lung cancer with specific mutations (those that lead to mesenchymal-epithelial transition or MET exon 14 skipping).

brand name

Tabrecta

General Description

Class: receptor tyrosine kinase; Treatment: NSCLC with METex14; Other name: INCB28060; Oral bioavailability >70%; Elimination half-life = 7.8 h; Protein binding = 96%

Side effects

Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.

Capmatinib Preparation Products And Raw materials

Raw materials

Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid Dimethyl sulfate

Preparation Products

Capmatinib Suppliers

Global( 279)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Zhengzhou Anhuida Chemical Co., Ltd	+8615903659408	China	294	58	Inquiry
Zison Pharmaceutical (Shandong) Co., Ltd.	+86-0086-531-88259693 +86-18660188356	China	57	58	Inquiry
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	China	294	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Zhengzhou Anhuida Chemical Co., Ltd	58
Zison Pharmaceutical (Shandong) Co., Ltd.	58
shandong perfect biotechnology co.ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

Capmatinib: Pharmacodynamics, Pharmacokinetics and Adverse Events
Capmatinib targets MET exon 14 skipping mutations, inhibiting proliferation and migration in non-small cell lung cancer. It ha....
Mar 1，2024

Can Capmatinib treat non-small cell lung cancer (NSCLC) in adults ?
Capmatinib is an FDA-approved targeted drug for the treatment of adult patients with non-small cell lung cancer(NSCLC).
Nov 8，2023

Capmatinib Spectrum

Capmatinib(1029712-80-8)¹HNMR

1029712-80-8(Capmatinib)Related Search:

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Selumetinib GSK1838705A Dasatinib SGX-523 Crizotinib

Lorlatinib (PF-06463922) BKM-120 INCB28060 Dihydrochloride Cabozantinib WZ4002

Dabrafenib Dacomitinib (PF299804) 1110813-31-4

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INCB028060 CapMatinib (INCB28060) CapMatinib NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- NVP-INC280 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060) INCB28060, INC280 BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- INCB28060 INC28060(BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-) INC 280 (INCB28060) INCB28060(Capmatinib) BenzaMide INCB28060 BenzaMide HCl CAPMATINIB (INCB28060);INCB-28060; INC-280 BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- CS-192 INCB 28060; INCB-28060; INC280 INC280 Capmatinib CAPMATINIB (INC280) INCB28060,BenzaMide NC280 2-fluoro-n-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide capmatinib Capmatinib base 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide Capmatinib USP/EP/BP INC28060 INCB28060 2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide INC280 Karma for, Valproic Acid Impurity 69 1029712-80-8 C23H17FN6O Inhibitors API