Alectinib manufacturers and suppliers in india

Alectinib

Properties

Melting point:: 274-276°C

Boiling point:: 722.5±60.0 °C(Predicted)

Density: 1.28

storage temp.: -20°

solubility: Soluble in DMSO (up to 5 mg/ml with warming).

form: solid

pka: 13.70±0.40(Predicted)

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361-H341-H373

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501

HS Code: 2934999090

Use

Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.