EAI-045
EAI-045
- CAS:
- 1942114-09-1
- MF:
- C19H14FN3O3S
- MW:
- 383.4
Suppliers by country/region
Company Type
Properties
- Density
- 1.546±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥38.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 7.20±0.50(Predicted)
- color
- White to khaki
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
EAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).
0 India supplier list of "EAI-045"
- Product Name:EAI045
- Products Intro:Brand:ajchemicals | Product Number:JDH-28634 | Purity:97%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:EAI045
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (EAI-045)
- Products Intro:Purity: 0.99 | Package: 5KG;1KG | CustNote: Have any requirements, pls contact sales@zetchem.com
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceutical, agrochemical, speciality chemical and liquid crystal industries.
- Product Name:EAI045
- Products Intro:Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for EAI045.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:EAI-045
- Products Intro:Purity: >=99% | Package: 1.8KG;9.8USD
- Company Type: Trader
- Country/Region: CHINA
$9.80/ 1.8KG
- Product Name:EAI-045
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chlorogenic acid,Tea polyphenol,Acacetin,Gentiopicroside,Jatrorrhizine
- Product Name:EAI045
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:EAI-045
- Products Intro:Purity: 98% | Package: 500g，1kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Nucleosides,Nucleotides,Amino acidsAmino Acid & Peptides,Carbohydrates,Ionic Liquids
- Product Name:EAI-045
- Products Intro:Purity: 0.95&0.99 | Package: 0.1KG;1KG;1000KG | CustNote: Wholesale price
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 89-32-7,101-80-4
- Product Name:EAI-045
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Fine Chemical,API,Raw Material,Pharmaceutical Compounds,Others