PLX-4720
- ₹0
- Product name: PLX-4720
- CAS: 918505-84-7
- MF: C17H14ClF2N3O3S
- MW: 413.83
- EINECS:
- MDL Number:MFCD14635203
- Synonyms:1-PropanesulfonaMide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-;N-[3-[(5-Chloro-1H-pyrrol...;N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide PLX 4720;PLX 4720 N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;PLX4720, >=98%;Raf Kinase Inhibitor V;PLX-4720, N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide;N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :230-233oC
Density :1.55
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Orange-yellow solid
pka :6.20±0.10(Predicted)
color :White to Off-White
Density :1.55
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Orange-yellow solid
pka :6.20±0.10(Predicted)
color :White to Off-White
Safety Information
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Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of wild type B-Raf. PLX4720 is an orally-available, highly selective inhibitor of B-RafV600E (IC50 = 13 nM). It is less effective against wild type B-Raf (IC50 = 160 nM) as well as several other kinases. PLX4720 induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf.Related product price
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Suppliers and manufacturers
career henan chemical co
A.J Chemicals
CLEARSYNTH LABS LTD.
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Shenzhen Nexconn Pharmatechs Ltd
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Shanghai Gubang New Materail Technology Co. LTD
₹1.00 /1KG
N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide CAS:918505-84-7
N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide CAS:918505-84-7