BI 2536
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- Product name: BI 2536
- CAS: 755038-02-9
- MF: C28H39N7O3
- MW: 521.65
- EINECS:1308068-626-2
- MDL Number:MFCD10565924
- Synonyms:BI-2536, BoehringerPLK-1 inhibitor;4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide;BI 2536;Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;Boehringer PLK-1 inhibitor;BI-2536(R-);BI2536/BI-2536;(R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
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Properties
Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI 2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM). It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI 2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice. It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells. BI 2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.More related product prices
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