PD 0332991 HCl
- ₹12940
- Product name: PD 0332991 HCl
- CAS: 827022-32-2
- MF: C24H30ClN7O2
- MW: 484
- EINECS:1592732-453-0
- MDL Number:MFCD22420809
- Synonyms:PD 0332991 HCl;PALBOCICLIB HCL; PD0332991 HCL;6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride Palbociclib (PD-0332991) HCl;Palbociclib hydrochloride, >=98%;PD-0332991 (Palbociclib);PD 0332991 hydrochloride;Palbociclib HCl;Palbociclib (hydrochloride)
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number5.30487
- Product descriptionStemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC?? = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk
- Packaging5MG
- Price₹12940
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 5.30487 | StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC?? = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk | 5MG | ₹12940 | 2022-06-14 | Buy |
Properties
storage temp. := -70C
solubility :≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow liquid
color :Light yellow to yellow
solubility :≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow liquid
color :Light yellow to yellow
Safety Information
Symbol(GHS): | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||
Precautionary statements: |
|
Description
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. Recently, PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.More related product prices
PD0332991 Isethionate 779353-01-4 871700-17-3 LEE011 MK-2206 2HCl 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER OTAVA-BB 1115529 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- sacubitril 89-25-8 Flupirtine maleate 3382-63-6 16133-25-8 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)- (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE OTAVA-BB 1207229 Olaparib LY2835219Related product price
- PD0332991 Isethionate
₹12297.2-50076.45 - OTAVA-BB 1115529
₹10684.28-43061.85 - 89-25-8
₹909-45529.95