Abemaciclib mesylate (LY2835219)
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- Product name: Abemaciclib mesylate (LY2835219)
- CAS: 1231930-82-7
- MF: C28H36F2N8O3S
- MW: 602.71
- EINECS:
- MDL Number:MFCD25562906
- Synonyms:2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1);N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine methanesulfonate (1:1) LY2835219;LY2835219 mesylate;Bemaciclib(salt);N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine,methanesulfonic acid;N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate;N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methyle;LY2835219 Ms salt, Abemaciclib Ms salt
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Properties
storage temp. :-20°
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
CAS DataBase Reference :1231930-82-7
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
CAS DataBase Reference :1231930-82-7
Safety Information
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Description
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.More related product prices
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