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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Hormonal antineoplastic drugs >Exemestane

Exemestane

Exemestane Structure
  • ₹11961.63 - ₹55218.33
  • Product name: Exemestane
  • CAS: 107868-30-4
  • MF: C20H24O2
  • MW: 296.4
  • EINECS:643-090-2
  • MDL Number:MFCD00866994
  • Synonyms:ExeMestane (USP);1,4-Androstadien-3,17-dione-6-Methylene-d2;(8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylene-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17(10H,14H)-dione;ExeMestine;(8R,9S,10R,13S,14S)-10,13-diMethyl-6-Methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione;ExeMestane SynonyMs 6-Methylenandrosta-1,4-diene-3,17-dione;PNU155971;Exemestane for system suitability
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1634
  • Product descriptionExemestane Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹11961.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0006
  • Product descriptionExemestane ≥98% (HPLC)
  • Packaging5MG
  • Price₹14115.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0006
  • Product descriptionExemestane ≥98% (HPLC)
  • Packaging25MG
  • Price₹55218.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1634 Exemestane Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹11961.63 2022-06-14 Buy
Sigma-Aldrich(India) PZ0006 Exemestane ≥98% (HPLC) 5MG ₹14115.8 2022-06-14 Buy
Sigma-Aldrich(India) PZ0006 Exemestane ≥98% (HPLC) 25MG ₹55218.33 2022-06-14 Buy

Properties

Melting point :155.13°C
Boiling point :453.7±45.0 °C(Predicted)
Density :1.13±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
color :white to off-white
optical activity :[α]/D +250 to +300°, c = 1 in methanol
InChI :InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChIKey :BFYIZQONLCFLEV-DAELLWKTSA-N
SMILES :C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C
CAS DataBase Reference :107868-30-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P391 Collect spillage. Hazardous to the aquatic environment

Description

Exemestane is a third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM; Kinact = 26 nM) that induces aromatase degradation leading to a decrease in estrogen levels in plasma. As an androgen analog, exemestane exhibits androgenic effects and has been shown to decrease total and HDL cholesterol, apo A1, and total triglyceride levels. Marketed under the trade name Aromasin?, exemestane has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.

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