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ChemicalBook > Product Catalogue >Chemical Reagents >Organic reagents >Esters >Methyl ester compound >Dimethyl fumarate

Dimethyl fumarate

Dimethyl fumarate Structure
  • ₹1859 - ₹9800
  • Product name: Dimethyl fumarate
  • CAS: 624-49-7
  • MF: C6H8O4
  • MW: 144.13
  • EINECS:210-849-0
  • MDL Number:MFCD00064438
  • Synonyms:But-2-enedioicaciddimethylester;Fumaric acid, bis-methyl ester;Dimethyl furmarate;DiMethyl fuMarate, 99% 100GR;DiMethyl fuMarate, 99% 25GR;trans-butenedioicacid,dimethylester ;trans-butenedioicaciddimethylester ;Dimethyl fumarate,99%
8 prices
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Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)
  • ALFA India

Package

  • 100MG
  • 25G
  • 100G
  • 250g
  • 500G
  • ManufacturerSigma-Aldrich(India)
  • Product number50744
  • Product descriptionDimethyl fumarate certified reference material, TraceCERT?
  • Packaging100MG
  • Price₹9504.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number242926
  • Product descriptionDimethyl fumarate 97%
  • Packaging100G
  • Price₹4070.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number242926
  • Product descriptionDimethyl fumarate 97%
  • Packaging25G
  • Price₹1948.5
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberF0069
  • Product descriptionDimethyl Fumarate min. 98.0 %
  • Packaging500G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberF0069
  • Product descriptionDimethyl Fumarate min. 98.0 %
  • Packaging25G
  • Price₹2100
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A10402-30
  • Product descriptionDimethyl fumarate, 99%
  • Packaging250g
  • Price₹8149
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A10402-22
  • Product descriptionDimethyl fumarate, 99%
  • Packaging100g
  • Price₹3699
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A10402-14
  • Product descriptionDimethyl fumarate, 99%
  • Packaging25g
  • Price₹1859
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 50744 Dimethyl fumarate certified reference material, TraceCERT? 100MG ₹9504.35 2022-06-14 Buy
Sigma-Aldrich(India) 242926 Dimethyl fumarate 97% 100G ₹4070.2 2022-06-14 Buy
Sigma-Aldrich(India) 242926 Dimethyl fumarate 97% 25G ₹1948.5 2022-06-14 Buy
TCI Chemicals (India) F0069 Dimethyl Fumarate min. 98.0 % 500G ₹9800 2022-05-26 Buy
TCI Chemicals (India) F0069 Dimethyl Fumarate min. 98.0 % 25G ₹2100 2022-05-26 Buy
ALFA India ALF-A10402-30 Dimethyl fumarate, 99% 250g ₹8149 2022-05-26 Buy
ALFA India ALF-A10402-22 Dimethyl fumarate, 99% 100g ₹3699 2022-05-26 Buy
ALFA India ALF-A10402-14 Dimethyl fumarate, 99% 25g ₹1859 2022-05-26 Buy

Properties

Melting point :102-106 °C (lit.)
Boiling point :192-193 °C (lit.)
Density :1,37 g/cm3
vapor pressure :5 hPa (25 °C)
refractive index :1.4062 (estimate)
Flash point :192-193°C
storage temp. :Store below +30°C.
solubility :1.6g/l
form :Liquid
color :Clear colorless to faintly yellow
PH :4.0-6.0 (10g/l, H2O, 20℃)suspension
Water Solubility :Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck :14,4287
BRN :774590
Stability :Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
CAS DataBase Reference :624-49-7(CAS DataBase Reference)
NIST Chemistry Reference :2-Butenedioic acid (E)-, dimethyl ester(624-49-7)
EPA Substance Registry System :2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways. It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate. Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels. It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis. Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.

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