Galeterone
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- ₹11539.45 - ₹46547.5
- Product name: Galeterone
- CAS: 851983-85-2
- MF: C26H32N2O
- MW: 388.55
- EINECS:806-537-4
- MDL Number:MFCD16660907
- Synonyms:NX41765;(3S,8R,9S,10R,13S,14S)-17-(1H-Benzo[d]imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;(3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol;Galeterone;VN 124;TOK-001 (Galeterone);Galeterone,TOK-001;(3S,10R,13S)-17-(1H-benzo[d]imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1375
- Product descriptionGaleterone ≥98% (HPLC)
- Packaging5MG
- Price₹11539.45
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1375
- Product descriptionGaleterone ≥98% (HPLC)
- Packaging25MG
- Price₹46547.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1375 | Galeterone ≥98% (HPLC) | 5MG | ₹11539.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1375 | Galeterone ≥98% (HPLC) | 25MG | ₹46547.5 | 2022-06-14 | Buy |
Properties
Melting point :189-190℃
Boiling point :564.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Ethyl Aceatae (Slightly, Heated)
pka :14.71±0.70(Predicted)
form :Solid
color :White to Off-White
InChIKey :PAFKTGFSEFKSQG-MRFMOSGMNA-N
SMILES :C1C[C@]2(C)C3CC[C@]4(C)C([n]5cnc6ccccc56)=CCC4C3CC=C2C[C@H]1O |&1:2,7,27,r|
Boiling point :564.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Ethyl Aceatae (Slightly, Heated)
pka :14.71±0.70(Predicted)
form :Solid
color :White to Off-White
InChIKey :PAFKTGFSEFKSQG-MRFMOSGMNA-N
SMILES :C1C[C@]2(C)C3CC[C@]4(C)C([n]5cnc6ccccc56)=CCC4C3CC=C2C[C@H]1O |&1:2,7,27,r|
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC50 = 300 nM) that has been shown to competitively block synthetic androgen binding (EC50 = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays. Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC50 value of 2.9 μM and demonstrates synergy with everolimus or gefitinib for growth inhibition.Related product price
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