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ChemicalBook > Product Catalogue >Organic Chemistry >Carboxylic acids and derivatives >Carboxylic acid esters and derivatives >Abiraterone acetate

Abiraterone acetate

Abiraterone acetate Structure
  • ₹4600 - ₹55077.6
  • Product name: Abiraterone acetate
  • CAS: 154229-18-2
  • MF: C26H33NO2
  • MW: 391.55
  • EINECS:620-314-7
  • MDL Number:MFCD00934213
  • Synonyms:Abiraterone acetate 99.5%;Abiraterone acetate(CB7630);3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene;2-((3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetate;Abiraterone acetate ester;Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-;Abiraterone Acetate impurity;(3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 200MG
  • 500MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberA2891
  • Product descriptionAbiraterone Acetate
  • Packaging200MG
  • Price₹4600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2891
  • Product descriptionAbiraterone Acetate
  • Packaging1G
  • Price₹9800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1527
  • Product descriptionAbiraterone acetate ≥98% (HPLC)
  • Packaging25MG
  • Price₹55077.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2410
  • Product descriptionAbiraterone Acetate Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹45529.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1527
  • Product descriptionAbiraterone acetate ≥98% (HPLC)
  • Packaging5MG
  • Price₹14224.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A2891 Abiraterone Acetate 200MG ₹4600 2022-05-26 Buy
TCI Chemicals (India) A2891 Abiraterone Acetate 1G ₹9800 2022-05-26 Buy
Sigma-Aldrich(India) SML1527 Abiraterone acetate ≥98% (HPLC) 25MG ₹55077.6 2022-06-14 Buy
Sigma-Aldrich(India) PHR2410 Abiraterone Acetate Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹45529.95 2022-06-14 Buy
Sigma-Aldrich(India) SML1527 Abiraterone acetate ≥98% (HPLC) 5MG ₹14224.05 2022-06-14 Buy

Properties

Melting point :127-130°C
Boiling point :506.7±50.0 °C(Predicted)
Density :1.14±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka :5.31±0.12(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

The cytochrome P450 (CYP) isoform CYP17A1 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Abiraterone acetate blocks CYP17A1 by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (IC50 = 18 and 17 nM, respectively). In mice as well as men, it essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone. It improves radiographic progression-free survival and significantly delays decline in human metastatic castration-resistant prostate cancer.

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Suppliers and manufacturers

Jigs Chemical ltd SGMR PHARMACEUTICALS PVT LTD Dr. Reddy's Laboratories Ltd Anant Pharmaceuticals Pvt Ltd Bulat Pharmaceutical Pvt Ltd TYNDAL LABS PVT LTD GLP Pharma Standards CDYMAX Hetero Drugs Limited Everest Organics Limited