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Abiraterone acetate

Abiraterone acetate Structure
CAS No.
154229-18-2
Chemical Name:
Abiraterone acetate
Synonyms
ZYTIGA;17-(3-pyridyl)-5,16-androstadien-3beta-acetate;Abiraterone Acotate;(3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester);(3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester);[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;CS-212;CB 7630;Abiraterone WS
CBNumber:
CB81396153
Molecular Formula:
C26H33NO2
Molecular Weight:
391.55
MOL File:
154229-18-2.mol
MSDS File:
SDS
Modify Date:
2024/5/18 8:51:57
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Abiraterone acetate Properties

Melting point 127-130°C
Boiling point 506.7±50.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka 5.31±0.12(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360-H372
Precautionary statements  P201-P202-P260-P264-P270-P308+P313
WGK Germany  3
RTECS  BV7992100
HS Code  2937290000
NFPA 704
0
2 0

Abiraterone acetate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1527 Abiraterone acetate ≥98% (HPLC) 154229-18-2 5MG ₹14224.05 2022-06-14 Buy
Sigma-Aldrich(India) SML1527 Abiraterone acetate ≥98% (HPLC) 154229-18-2 25MG ₹55077.6 2022-06-14 Buy
Sigma-Aldrich(India) PHR2410 Abiraterone Acetate Pharmaceutical Secondary Standard; Certified Reference Material 154229-18-2 500MG ₹45529.95 2022-06-14 Buy
TCI Chemicals (India) A2891 Abiraterone Acetate 154229-18-2 200MG ₹4600 2022-05-26 Buy
TCI Chemicals (India) A2891 Abiraterone Acetate 154229-18-2 1G ₹9800 2022-05-26 Buy
Product number Packaging Price Buy
SML1527 5MG ₹14224.05 Buy
SML1527 25MG ₹55077.6 Buy
PHR2410 500MG ₹45529.95 Buy
A2891 200MG ₹4600 Buy
A2891 1G ₹9800 Buy

Abiraterone acetate Chemical Properties,Uses,Production

Description

In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).

Chemical Properties

Off-White Solid

Uses

Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

Definition

ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .

Abiraterone acetate Preparation Products And Raw materials

Raw materials

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Abiraterone (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate) 3-Pyridylboronic acid DIETHYL(3-PYRIDYL)BORANE
3-Pyridyl bromide Dehydroepiandrosterone acetate
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Preparation Products

Abiraterone acetate Suppliers

Global( 563)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Anant Pharmaceuticals Pvt Ltd +91-8550986868 +91-9485998001 Haryana, India 461 58 Inquiry
Bulat Pharmaceutical Pvt Ltd +91-8448085659 +91-8448085660 Haryana, India 123 58 Inquiry
TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
CDYMAX +91-9019317788 +91-9019317788 Bangalore, India 28 58 Inquiry
Cipla Ltd +912224826000 Maharashtra, India 133 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
SGMR PHARMACEUTICALS PVT LTD 58
Dr. Reddy's Laboratories Ltd 58
Anant Pharmaceuticals Pvt Ltd 58
Bulat Pharmaceutical Pvt Ltd 58
TYNDAL LABS PVT LTD 58
GLP Pharma Standards 58
CDYMAX 58
Cipla Ltd 58
Hetero Drugs Limited 58

Abiraterone acetate Spectrum

Abiraterone acetate(154229-18-2)1HNMR

154229-18-2(Abiraterone acetate)Related Search:

ETOFIBRATE ABiraterone impurity 15 Abiraterone Acetate Dimer Impurity (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate) DIETHYL(3-PYRIDYL)BORANE
Abiraterone Sulfate Sodium Salt Abiraterone Impurity 4 Abiraterone Ethyl Ether Dehydroepiandrosterone acetate Abiraterone
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene Abiraterone Related Compound 8 Dehydroepiandrosterone Abiraterone Sulfate Abiraterone Related CoMpound 2 (Prasterone Triflate)
Abiraterone N-Oxide Abiraterone DiMer IMpurity (Prasteronyl Abiraterone) 17-Iodoandrosta-5,16-dien-3beta-ol
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Abiraterone acetate 99.5% Abiraterone acetate(CB7630) 3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene 2-((3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetate Abiraterone acetate ester Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)- Abiraterone Acetate impurity (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate Abiraterone acetate, >=99% Abirteroneacetate 2-((3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodec Abiraterone Acetate CB 7630 Abiraterone acetate - CB 7630 | JNJ 212082 CS-212 Androsta-5,16-dien-3-ol,17-(3-pyridinyl) 3-Epi-abiraterone Acetate stereoisomer Abiraterone Acetate > 17-(3-pyridyl)-5,16-androstadien-3beta-acetatee 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)- ABITATERONE ACETATE Abiraterone Impurity 81 3beta-17-(3-Pyridyl)androsta-5,16-dien-3-ol Acetate Abiraterone acetate ISO 9001：2015 REACH (3aS,3bR,7S,9aR,9bS,11aS)-9a,11a-dimethyl-1-(pyridin-3-yl)-3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate Abiraterone acetate (USFDA) Abiraterone acetate- USP Abiraterone Acetate CAS 154229-18-2 (3β)-17-(3-pyridyl)- androsta-5,16-dien-3-ol-acetate Abiraterone Acetate (Zytiga formerly CB-7598 Abiraterone Acetate D4Q: What is Abiraterone Acetate D4 Q: What is the CAS Number of Abiraterone Acetate D4 Q: What is the storage condition of Abiraterone Acetate D4 Q: What are the applications of Abiraterone Acetate D4 Abiraterone Acetate (1000818) 8-Dihydroxyquinaldic acid (3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester) (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate 17-(3-pyridyl)-5,16-androstadien-3beta-acetate (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester) ZYTIGA Abiraterone Acotate [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)- Abiteron Acetate Abiraterone WS (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(3-pyridyl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl Acetate 154229-18-2 54229-18-2 C26H32NO2 Inhibitors Inhibitor Final material Anti-cancer & immunity DQM API Intermediates & Fine Chemicals Pharmaceuticals Steroids