Abiraterone acetate
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Abiraterone acetate 속성
- 녹는점
- 127-130°C
- 끓는 점
- 506.7±50.0 °C(Predicted)
- 밀도
- 1.14±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 5.31±0.12(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 | ||
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RTECS 번호 | BV7992100 | ||
HS 번호 | 2937290000 |
Abiraterone acetate C화학적 특성, 용도, 생산
개요
In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).화학적 성질
Off-White Solid용도
Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.정의
ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .Abiraterone acetate 준비 용품 및 원자재
원자재
3-피리딘붕소산 피나콜 에스테르
아비라테론
(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)
3-Pyridylboronic acid
디에틸(옥시-피라질)보란
3-브로모피리딘
Dehydroepiandrosterone acetate
준비 용품
Abiraterone acetate 공급 업체
글로벌( 563)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Joyochem Co.,Ltd | +86-0531-82687558 +8613290333633 |
sales@joyochem.com | China | 41 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12460 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 |
info@millionpharm.com | China | 191 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Abiraterone acetate 관련 검색:
ETOFIBRATE
ABiraterone impurity 15
Abiraterone Acetate Dimer Impurity
(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)
DIETHYL(3-PYRIDYL)BORANE
Abiraterone Sulfate Sodium Salt
Abiraterone Impurity 4
Abiraterone Ethyl Ether
Dehydroepiandrosterone acetate
Abiraterone
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene
Abiraterone Related Compound 8
Dehydroepiandrosterone
Abiraterone Sulfate
Abiraterone Related CoMpound 2 (Prasterone Triflate)
Abiraterone N-Oxide
Abiraterone DiMer IMpurity (Prasteronyl Abiraterone)
17-Iodoandrosta-5,16-dien-3beta-ol