Binimetinib
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- ₹0
- Product name: Binimetinib
- CAS: 606143-89-9
- MF: C17H15BrF2N4O3
- MW: 441.23
- EINECS:
- MDL Number:MFCD22124525
- Synonyms:5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;MEK162 (ARRY-438162);MEK162 (ARRY-162, ARRY-438162);BiniMetinib (MEK162, ARRY-162, ARRY-438162);1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-;5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Binimetinib (MEK162, ARRY-162, ARRY-438162);ARRY-438162 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;Binimetinib
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Properties
Melting point :>203oC (dec.)
Density :1.67
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :14.20±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.67
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :14.20±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM). It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM). This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-Raf mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.Related product price
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