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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >MEK inhibitor >PD 0325901

PD 0325901

PD 0325901 Structure
  • ₹15891.1 - ₹60457.63
  • Product name: PD 0325901
  • CAS: 391210-10-9
  • MF: C16H14F3IN2O4
  • MW: 482.19
  • EINECS:687-152-7
  • MDL Number:MFCD08435926
  • Synonyms:N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;PD 0325901;(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide;PD-0235901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be;N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901;PD 0325901 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0162
  • Product descriptionPD 0325901 ≥98% (HPLC)
  • Packaging5MG
  • Price₹15891.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number444968
  • Product descriptionInSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem The InSolution MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule
  • Packaging5MG
  • Price₹17860
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number444966
  • Product descriptionMEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primaril
  • Packaging5MG
  • Price₹23160
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0162
  • Product descriptionPD 0325901 ≥98% (HPLC)
  • Packaging25MG
  • Price₹60457.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0162 PD 0325901 ≥98% (HPLC) 5MG ₹15891.1 2022-06-14 Buy
Sigma-Aldrich(India) 444968 InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem The InSolution MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule 5MG ₹17860 2022-06-14 Buy
Sigma-Aldrich(India) 444966 MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primaril 5MG ₹23160 2022-06-14 Buy
Sigma-Aldrich(India) PZ0162 PD 0325901 ≥98% (HPLC) 25MG ₹60457.63 2022-06-14 Buy

Properties

Melting point :112-114°C
Density :1.817±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :White to off-white solid
pka :13.45±0.20(Predicted)
color :white to off-white
optical activity :[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :SUDAHWBOROXANE-SECBINFHSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation with 1 μM PD 0325901 combined with 3 μM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.

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