PD184352
- ₹9800 - ₹51884.23
- Product name: PD184352
- CAS: 212631-79-3
- MF: C17H14ClF2IN2O2
- MW: 478.66
- EINECS:
- MDL Number:MFCD02683961
- Synonyms:CI1040;PD-184352; CI 1040 (PD184352);CS-333;PD184352;2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE;2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-;Ci-1040
4 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberP2174
- Product descriptionPD 184352
- Packaging25MG
- Price₹9800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberP2174
- Product descriptionPD 184352
- Packaging100MG
- Price₹32500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0181
- Product descriptionPD184352 ≥98% (HPLC)
- Packaging5MG
- Price₹12979.18
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0181
- Product descriptionPD184352 ≥98% (HPLC)
- Packaging25MG
- Price₹51884.23
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | P2174 | PD 184352 | 25MG | ₹9800 | 2022-05-26 | Buy |
TCI Chemicals (India) | P2174 | PD 184352 | 100MG | ₹32500 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | PZ0181 | PD184352 ≥98% (HPLC) | 5MG | ₹12979.18 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0181 | PD184352 ≥98% (HPLC) | 25MG | ₹51884.23 | 2022-06-14 | Buy |
Properties
Melting point :166-169°C
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
Safety Information
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Signal word: | Warning | ||||||||||||||
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Precautionary statements: |
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Description
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate). It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model. The second-generation MEK inhibitor PD 0325901 is a structural derivative of CI-1040 that was developed for improved solubility.Related product price
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