PD 173074
![]() |
- ₹4600 - ₹88981.5
- Product name: PD 173074
- CAS: 219580-11-7
- MF: C28H41N7O3
- MW: 523.67
- EINECS:
- MDL Number:MFCD08705327
- Synonyms:n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea;N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d ]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD173074/PD-173074;1-(tert-butyl)-3-(2-((4-(diethylaMino)butyl)aMino)-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)urea;1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-;Urea, N-[2-[[4-(diethylaMino)butyl]aMino]-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl)-;PD176074;N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea PD 173074
6 prices
Selected condition:
Brand
- Sigma-Aldrich
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- 50MG
- ManufacturerSigma-Aldrich
- Product number341607
- Product descriptionFGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.
- Packaging5MG
- Price₹21460
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberP2474
- Product descriptionPD 173074
- Packaging10MG
- Price₹4600
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberP2474
- Product descriptionPD 173074
- Packaging50MG
- Price₹17500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number341607
- Product descriptionFGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Ph
- Packaging5MG
- Price₹21460
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP2499
- Product descriptionPD 173074 ≥96% (HPLC), powder
- Packaging5MG
- Price₹21898.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP2499
- Product descriptionPD 173074 ≥96% (HPLC), powder
- Packaging25MG
- Price₹88981.5
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich | 341607 | FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications. | 5MG | ₹21460 | 2022-06-14 | Buy |
TCI Chemicals (India) | P2474 | PD 173074 | 10MG | ₹4600 | 2022-05-26 | Buy |
TCI Chemicals (India) | P2474 | PD 173074 | 50MG | ₹17500 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | 341607 | FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Ph | 5MG | ₹21460 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | P2499 | PD 173074 ≥96% (HPLC), powder | 5MG | ₹21898.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | P2499 | PD 173074 ≥96% (HPLC), powder | 25MG | ₹88981.5 | 2022-06-14 | Buy |
Properties
Melting point :82-85°C
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1.163
storage temp. :2-8°C
solubility :DMSO: 21 mg/mL
form :solid
pka :10.12±0.43(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
Symbol(GHS): |
![]() |
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM. For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC. PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.More related product prices
Olaparib 918504-65-1 872511-34-7 MK-2206 2HCl AZD-4547 Verdinexor (KPT-335) KPT-330 (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- Motesanib 371242-69-2 N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE JNJ-10198409 Pictilisib (GDC-0941) PD 123,319 DITRIFLUOROACETATE PD 0325901 PD 166866 PD 166285 BEZ235 (NVP-BEZ235, Dactolisib) ERK Inhibitor Compound 23Related product price
- N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
₹25060.01 - JNJ-10198409
₹19050-78719.4 - PD 0325901
₹15891.1-60457.63