NVP-BEZ 235
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- Product name: NVP-BEZ 235
- CAS: 915019-65-7
- MF: C30H23N5O
- MW: 469.55
- EINECS:1312995-182-4
- MDL Number:MFCD10565944
- Synonyms:4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile;BEZ-235;2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile;2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile;BEZ235 (NVP-BEZ235, Dactolisib);2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl;BEZ235 NVP-BEZ235(BEZ235);Dactolisib
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Properties
Melting point :288-289°C
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka :6.41±0.20(Predicted)
form :White powder.
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference :915019-65-7
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75?C).
pka :6.41±0.20(Predicted)
form :White powder.
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
CAS DataBase Reference :915019-65-7
Safety Information
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Description
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.More related product prices
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