Siremadlin
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- ₹0
- Product name: Siremadlin
- CAS: 1448867-41-1
- MF: C26H24Cl2N6O4
- MW: 555.41
- EINECS:
- MDL Number:MFCD30502893
- Synonyms:(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one;Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-;Siremadlin (NVP-HDM201);NVP-HDM201;CS-2613;CS-2787;HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :736.5±70.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 56.75 mg/mL (102.18 mM)
form :Solid
pka :1.33±0.29(Predicted)
color :White to off-white
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 56.75 mg/mL (102.18 mM)
form :Solid
pka :1.33±0.29(Predicted)
color :White to off-white
Safety Information
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Description
Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies.
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