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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Angiogenesis >FAK inhibitors >TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) Structure
  • ₹0
  • Product name: TAE226 (NVP-TAE226)
  • CAS: 761437-28-9
  • MF: C23H25ClN6O3
  • MW: 468.94
  • EINECS:
  • MDL Number:MFCD12031516
  • Synonyms:NVP-TAE 226;TAE226;TAE226 (NVP-TAE226);2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-;NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;TAE226 (NVP-TAE226) USP/EP/BP
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.349
storage temp. :Store at -20°C
solubility :≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :14.57±0.46(Predicted)
color :White to khaki

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.

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Related product price

Suppliers and manufacturers

career henan chemical co
TAE226 (NVP-TAE226)
₹1.00 /1KG
TAE226 (NVP-TAE226) CAS:761437-28-9
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Coresyn Pharmatech Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.