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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Other antineoplastic Drugs >Bortezomib

Bortezomib

Bortezomib Structure
  • ₹12940
  • Product name: Bortezomib
  • CAS: 179324-69-7
  • MF: C19H25BN4O4
  • MW: 384.24
  • EINECS:605-854-3
  • MDL Number:MFCD09056737
  • Synonyms:Boronic acid, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]bu;MG-341 PS-341;BortezoMib Base;bortezoMib(other);MLM341;BortezoMib R;VELCADE(BORTEZOMIB);Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.04314
  • Product descriptionBortezomib - CAS 179324-69-7 - Calbiochem Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- a
  • Packaging5MG
  • Price₹12940
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.04314 Bortezomib - CAS 179324-69-7 - Calbiochem Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- a 5MG ₹12940 2022-06-14 Buy

Properties

Melting point :122-124°C
Density :1.214
RTECS :ED7771666
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.
form :solid
pka :9.66±0.43(Predicted)
color :White
Stability :Hygroscopic and Moisture Sensitive
CAS DataBase Reference :179324-69-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger GHS hazard pictograms P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger GHS hazard pictograms P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P405 Store locked up.

Description

Bortezomib, a modified dipeptidyl boronic acid, is a therapeutic proteasome inhibitors used for the treatment of cancers. It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting the mammalian 26S proteasome, which is important in regulating the intracellular concentration of specific proteins to maintain homeostasis within cells. The disruption of 26S proteasome function disrupts normal cellular homeostasis, leading to cytotoxic effect on various kinds of cancer cells. 

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