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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >Luminespib

Luminespib

Luminespib Structure
  • ₹0
  • Product name: Luminespib
  • CAS: 747412-49-3
  • MF: C26H31N3O5
  • MW: 465.54
  • EINECS:
  • MDL Number:MFCD14635361
  • Synonyms:5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide;AUY922 (NVP-AUY922);VER 52296;VER-52296;NVP-AUY922;AUY 922;LuMinespib;Luminespib (AUY-922, NVP-AUY922)
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :180-184°C
Boiling point :640.1±55.0 °C(Predicted)
Density :1.234
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :8.47±0.48(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference :747412-49-3

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

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