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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >Luminespib

Luminespib

Luminespib Structure
CAS No.
747412-49-3
Chemical Name:
Luminespib
Synonyms
CS-209;AUY 922;VER-52296;VER 52296;LuMinespib;NVP-AUY922;NVP-AUY922-NX;AUY922, VER-52296;NVP-AUY922, >=98%;AUY922 (NVP-AUY922)
CBNumber:
CB22489931
Molecular Formula:
C26H31N3O5
Molecular Weight:
465.54
MOL File:
747412-49-3.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:58
Request For Quotation

Luminespib Properties

Melting point 180-184°C
Boiling point 640.1±55.0 °C(Predicted)
Density 1.234
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
pka 8.47±0.48(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference 747412-49-3

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  2934999090
NFPA 704
0
2 0

Luminespib Chemical Properties,Uses,Production

Description

Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-AUY922 is a Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI50s averaging 9 nM. In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls. Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.

Luminespib Preparation Products And Raw materials

Raw materials

Preparation Products

Luminespib Suppliers

Global( 156)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10326 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Hubei Ipure Biology Co., Ltd 58

Luminespib Spectrum

Luminespib(747412-49-3)1HNMR

747412-49-3(Luminespib)Related Search:

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BI 2536 NORFLUOXETINE HYDROCHLORIDE 1-(4-Methylphenyl)ethanol Bortezomib KU-55933 (ATM Kinase Inhibitor)
Crizotinib 17-AAG CHIR-99021 Ganetespib
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5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide AUY922 (NVP-AUY922) VER 52296 VER-52296 NVP-AUY922 AUY 922 LuMinespib Luminespib (AUY-922, NVP-AUY922) AUY922,NVP-AUY-922,Luminespib 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide AUY922 (NVP-AUY922) Luminespib (NVP-AUY922) AUY922, VER-52296 NVP-AUY922, >=98% NVP-AUY922, Luminespib, VER52296 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxam 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide USP/EP/BP 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]- 17-AAG, Hsp90 inhibitor NVP-AUY922, Hsp90 Inhibitor AUY922; AUY-922; AUY 922; NVP AUY922; NVP AUY-922; VER52296 ; VER-52296 ; VER 52296 ; LUMINESPIB LUMINESPIB;NVP-AUY922;VER-52296;NVP-AUY 922;AUY-922;VER 52296;VER52296 AUY922 (Luminespib,NVP-AUY922) NVP-AUY922 - VER 52296 | Luminespib NVP-AUY922-NX AUY 922;AUY-922; NVP-AUY922;NVP-AUY922-NX;AUY922;VER-52296 CS-209 NVP-AUY922 (Luminespib AUY-922 (LUMINESPIB) AUY-922,Luminespib,AUY 922,Inhibitor,HSP,Autophagy,Heat shock proteins,VER52296,Apoptosis,inhibit,VER 52296 747412-49-3 API Intermediates & Fine Chemicals Pharmaceuticals Inhibitor Potent and oral inhibitor of heat shock protein 90. Aromatics Heterocycles Inhibitors Antineoplastic