Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >Ganetespib

Ganetespib

Ganetespib Structure
CAS No.
888216-25-9
Chemical Name:
Ganetespib
Synonyms
CS-654;SAT9090;STA-9090;Ganetespib;STA-9090;STA9090;Ganetespib, >=98%;STA-9090/Ganetespib;Ganetespib USP/EP/BP;Ganetespib (STA-9090);STA-9090; STA 9090; STA9090
CBNumber:
CB02566762
Molecular Formula:
C20H20N4O3
Molecular Weight:
364.4
MOL File:
888216-25-9.mol
MSDS File:
SDS
Modify Date:
2023/7/9 14:26:36
Request For Quotation

Ganetespib Properties

Density 1.39
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form solid
pka 7.38±0.20(Predicted)
color White
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
HS Code  2933998090

Ganetespib Chemical Properties,Uses,Production

Description

Ganetespib, also known as STA-9090, is a unique resorcinolic triazolone inhibitor of Hsp90, which is currently in clinical trials for a number of human cancers. It has shown promise in preclinical tests against various cancers, including lung cancer, prostate cancer, and leukemia. Moreover, It has also shown strong activity toward breast cancer, non-small cell lung cancer, gastric cancer, and acute myeloid leukemia.

Definition

ChEBI: Ganetespib is a member of triazoles and a ring assembly. It is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

References

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer DOI:10.1158/1078-0432.CCR-11-2967
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ganetespib
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy DOI: 10.1158/1535-7163.MCT-11-0755
Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice doi: 10.3390/ijms24055014
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies DOI:10.1186/1471-2407-13-152
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner DOI:10.1038/cddis.2017.108

Ganetespib Preparation Products And Raw materials

Raw materials

Preparation Products

Ganetespib Suppliers

Global( 144)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9624 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang ZETian Fine Chemicals Co. LTD 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Finetech Industry Limited 58

Ganetespib Spectrum

Ganetespib(888216-25-9)1HNMR

888216-25-9(Ganetespib)Related Search:

RESINIFERATOXIN ML335 Dequalinium chloride Volasertib (BI 6727) Histamine
Aspartate aminotransferase Docetaxel Flavopiridol Epacadostat (INCB024360) Ilomastat
Tazemetostat (EPZ-6438) BIIB-021 Dabrafenib Onalespib Trametinib
Luminespib
chevron_left

1of4

chevron_right
5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganetespib (STA-9090) 3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-Methylethyl)phenyl]-2,4-dihydro-4-(1-Methyl-1H-indol-5-yl)- SAT9090 2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one 5-{1,5-Dihydro-3-[2,4-dihydroxy-5-(prop-2-yl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl}-1-methyl-1H-indole, 4-[4,5-Dihydro-4-(1-methyl-1H-indol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-6-(prop-2-yl)benzene-1,3-di ol 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one STA-9090/Ganetespib 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganete ganetespib (Hsp90 inhibitor) 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one STA-9090;STA9090 GANETESPIB (STA-9090);STA-9090;STA 9090;STA9090 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-tria Ganetespib, >=98% Ganetespib STA-9090 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole STA9090; STA 9090; STA-9090; GANETESPIB STA-9090; STA 9090; STA9090 CS-654 3-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one Ganetespib USP/EP/BP (5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one 888216-25-9 Inhibitors