ガネテスピブ
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- CAS番号.
- 888216-25-9
- 化学名:
- ガネテスピブ
- 别名:
- 2,4-ジヒドロ-5-[2,4-ジヒドロキシ-5-イソプロピルフェニル]-4-(1-メチル-1H-インドール-5-イル)-3H-1,2,4-トリアゾール-3-オン;ガネテスピブ;3-[2,4-ジヒドロキシ-5-(プロパン-2-イル)フェニル]-4-(1-メチル-1H-インドール-5-イル)-4,5-ジヒドロ-1H-1,2,4-トリアゾール-5-オン;5-(2,4-ジヒドロキシ-5-イソプロピルフェニル)-2,4-ジヒドロ-4-(1-メチル-1H-インドール-5-イル)-3H-1,2,4-トリアゾール-3-オン;3-(2,4-ジヒドロキシ-5-イソプロピルフェニル)-4-(1-メチル-1H-インドール-5-イル)-1H-1,2,4-トリアゾール-5(4H)-オン
- 英語名:
- Ganetespib
- 英語别名:
- CS-654;SAT9090;STA-9090;Ganetespib;STA-9090;STA9090;Ganetespib, >=98%;STA-9090/Ganetespib;Ganetespib USP/EP/BP;Ganetespib (STA-9090);STA-9090; STA 9090; STA9090
- CBNumber:
- CB02566762
- 化学式:
- C20H20N4O3
- 分子量:
- 364.4
- MOL File:
- 888216-25-9.mol
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ガネテスピブ 物理性質
- 比重(密度) :
- 1.39
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO に可溶 (少なくとも 25 mg/ml まで)
- 外見 :
- 個体
- 酸解離定数(Pka):
- 7.38±0.20(Predicted)
- 色:
- 白い
- 安定性：:
- -20°C の DMSO 溶液で最大 3 か月間保存できます。
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-1381 |
Ganetespib |
888216-25-9 |
100mg |
￥258500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR305233 |
2,4-ジヒドロ-5-[2,4-ジヒドロキシ-5-イソプロピルフェニル]-4-(1-メチル-1H-インドール-5-イル)-3H-1,2,4-トリアゾール-3-オン
2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one |
888216-25-9 |
250mg |
￥429600 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-1381 |
ガネテスピブ
Ganetespib |
888216-25-9 |
250mg |
￥309600 |
2020-09-21 |
購入 |
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富士フイルム和光純薬株式会社(wako)
|
W01FLC468363 |
GANETESPIB |
888216-25-9 |
250mg |
￥272500 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC468363 |
GANETESPIB |
888216-25-9 |
1g |
￥680600 |
2021-03-23 |
購入 |
ガネテスピブ 化学特性,用途語,生産方法
効能
抗悪性腫瘍薬, 熱ショックタンパク質阻害薬
説明
Ganetespib, also known as STA-9090, is a unique resorcinolic triazolone inhibitor of Hsp90, which is currently in clinical trials for a number of human cancers. It has shown promise in preclinical tests against various cancers, including lung cancer, prostate cancer, and leukemia. Moreover, It has also shown strong activity toward breast cancer, non-small cell lung cancer, gastric cancer, and acute myeloid leukemia.
定義
ChEBI: Ganetespib is a member of triazoles and a ring assembly. It is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
参考文献
Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer DOI:
10.1158/1078-0432.CCR-11-2967 https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ganetespib
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy DOI:
10.1158/1535-7163.MCT-11-0755Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice doi:
10.3390/ijms24055014
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies DOI:
10.1186/1471-2407-13-152
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner DOI:
10.1038/cddis.2017.108
ガネテスピブ 上流と下流の製品情報
原材料
準備製品
ガネテスピブ 生産企業
Global( 145)Suppliers
888216-25-9(ガネテスピブ)キーワード:
- 888216-25-9
- 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one
- Ganetespib (STA-9090)
- 3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-Methylethyl)phenyl]-2,4-dihydro-4-(1-Methyl-1H-indol-5-yl)-
- SAT9090
- 2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one
- 5-{1,5-Dihydro-3-[2,4-dihydroxy-5-(prop-2-yl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl}-1-methyl-1H-indole, 4-[4,5-Dihydro-4-(1-methyl-1H-indol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-6-(prop-2-yl)benzene-1,3-di
ol
- 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one
- STA-9090/Ganetespib
- 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganete
- ganetespib (Hsp90 inhibitor)
- 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one
- STA-9090;STA9090
- GANETESPIB (STA-9090);STA-9090;STA 9090;STA9090
- 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-tria
- Ganetespib, >=98%
- Ganetespib
- STA-9090
- 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole
- STA9090; STA 9090; STA-9090; GANETESPIB
- STA-9090; STA 9090; STA9090
- CS-654
- 3-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one
- Ganetespib USP/EP/BP
- (5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one
- 2,4-ジヒドロ-5-[2,4-ジヒドロキシ-5-イソプロピルフェニル]-4-(1-メチル-1H-インドール-5-イル)-3H-1,2,4-トリアゾール-3-オン
- ガネテスピブ
- 3-[2,4-ジヒドロキシ-5-(プロパン-2-イル)フェニル]-4-(1-メチル-1H-インドール-5-イル)-4,5-ジヒドロ-1H-1,2,4-トリアゾール-5-オン
- 5-(2,4-ジヒドロキシ-5-イソプロピルフェニル)-2,4-ジヒドロ-4-(1-メチル-1H-インドール-5-イル)-3H-1,2,4-トリアゾール-3-オン
- 3-(2,4-ジヒドロキシ-5-イソプロピルフェニル)-4-(1-メチル-1H-インドール-5-イル)-1H-1,2,4-トリアゾール-5(4H)-オン