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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >Onalespib

Onalespib

Onalespib Structure
CAS No.
912999-49-6
Chemical Name:
Onalespib
Synonyms
CS-1866;AT-13387;Onalespib;ATI-13387;ATI13387X;AT13387, >=98%;Onalespib Lactate;AT13387(Onalespib);Onalespib (AT13387);ONALESPIB;ATI-13387
CBNumber:
CB32566420
Molecular Formula:
C24H31N3O3
Molecular Weight:
409.52
MOL File:
912999-49-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06
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Onalespib Properties

Boiling point 605.7±55.0 °C(Predicted)
Density 1.237
storage temp. Store at -20°C
solubility insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form solid
pka 8.50±0.48(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P305+P351+P338

Onalespib Chemical Properties,Uses,Production

Description

Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.

Mode of action

Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins and has been used as a biomarker of HSP90 inhibition.

References

Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas
https://pubchem.ncbi.nlm.nih.gov/compound/Onalespib

Onalespib Preparation Products And Raw materials

Raw materials

Preparation Products

Onalespib Suppliers

Global( 114)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10326 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
Hubei Ipure Biology Co., Ltd 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Nanjing Doge Biomedical Technology Co., Ltd 58

Onalespib Spectrum

(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone(912999-49-6)1HNMR

912999-49-6(Onalespib)Related Search:

Bortezomib BIIB-021 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide PU-H71 Flavopiridol (Alvocidib) HCl
Ganetespib
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(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone AT-13387 4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone Onalespib Onalespib (AT13387) [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387 AT13387, >=98% Onalespib Lactate (2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone USP/EP/BP Methanone, [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]- ONALESPIB;ATI-13387 ATI-13387 (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone AT13387(Onalespib) CS-1866 ATI13387X Onalespib AT-13387 AT13387 912999-49-6 12999-49-6 Inhibitor Inhibitors