Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >CDK inhibitors >FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE Structure
CAS No.
131740-09-5
Chemical Name:
FLAVOPIRIDOL HYDROCHLORIDE
Synonyms
HL 275;CS-976;L-86-8276;NSC 649890;MDL 107826A;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HC;Flavopiridol HCI;FLAVOPIRIDOL HCL
CBNumber:
CB1972179
Molecular Formula:
C21H21Cl2NO5
Molecular Weight:
438.3
MOL File:
131740-09-5.mol
Modify Date:
2024/11/17 16:00:36
Request For Quotation

FLAVOPIRIDOL HYDROCHLORIDE Properties

Melting point 169.5-170°C
alpha 24D -1.73 to -3.9°
storage temp. 2-8°C
solubility H2O: ~2mg/mL
pka 5.68 ± 0.06(at 25℃)
form powder
color white to light brown
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference 131740-09-5

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  DJ2978830
NFPA 704
0
2 0

FLAVOPIRIDOL HYDROCHLORIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) F3055 Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder 131740-09-5 5MG ₹14873.55 2022-06-14 Buy
Sigma-Aldrich(India) F3055 Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder 131740-09-5 25MG ₹59396.78 2022-06-14 Buy
Product number Packaging Price Buy
F3055 5MG ₹14873.55 Buy
F3055 25MG ₹59396.78 Buy

FLAVOPIRIDOL HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.

Chemical Properties

Yellow Powder

Uses

Flavopiridol hydrochloride hydrate has been used:

  • as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
  • as an RNA polymerase inhibitor to study its effects on hepatic cells
  • as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.

FLAVOPIRIDOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FLAVOPIRIDOL HYDROCHLORIDE Suppliers

Global( 147)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32951 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29884 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39894 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49374 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32080 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22883 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52849 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58

FLAVOPIRIDOL HYDROCHLORIDE Spectrum

FLAVOPIRIDOL HYDROCHLORIDE(131740-09-5)1HNMR

131740-09-5(FLAVOPIRIDOL HYDROCHLORIDE)Related Search:

CL 82198 HYDROCHLORIDE Diethanolamine Uracil Dihydroxybenzoic acid Resorcinol
3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Dihydrocaffeic acid Diphenylphosphine oxide Alisertib (MLN8237) SNS-032
Dasatinib PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PLX4032 Flavopiridol (Alvocidib) HCl
Flavopiridol 2'-chloroflavone ROHITUKINE
chevron_left

1of4

chevron_right
Flavopiridol (Alvocidib)hcl Flavopiridol HCI L-86-8276 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride NSC 649890 HCl (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride Flavopiridol hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride, >=98% Alvocidib HCL Flavopiridol (Alvocidib) hydrochloride Flavopiridol hydrochloride hydrate FLAVOPIRIDOL HYDROCHLORIDE FLAVOPIRIDOL HCL Alvocidib Hydrochloride HL 275 MDL 107826A NSC 649890 rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride L-86-8276, NSC-649890, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidinyl]-4h-1-benzopyran-4-one hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis- 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy- 1-methyl-4-piperidinyl]-, hydrochloride, rel- CS-976 FLAVOPIRIDOL HYDROCHLORIDE USP/EP/BP 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride NSC-649890 hydrochloride HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; ALVOCIDIB HYDROCHLORIDE Flavopiridol HC Flavopiridol (L86-8275) HCl Alvocidib Hydrochloride|||NSC 649890|||MDL 107826A|||HL 275|||FLAVOPIRIDOL HCL|||NSC 649890 HCl 131740-09-5 C21H20ClNO5HCl C21H21Cl2NO5 Inhibitors Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals