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SNS-032

SNS-032 Structure
CAS No.
345627-80-7
Chemical Name:
SNS-032
Synonyms
CS-202;SNS-032;BMS-387032;BMS-3870032;SNS-032, >=99%;BMS-387032/SNS-032;SNS0032(BMS-387032);SNS-032, 98.5%, a selective CDK2 inhibitor;BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032;1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]-
CBNumber:
CB51518701
Molecular Formula:
C17H24N4O2S2
Molecular Weight:
380.53
MOL File:
345627-80-7.mol
Modify Date:
2023/9/4 16:42:00
Request For Quotation

SNS-032 Properties

Melting point 171-173 °C
Density 1.28±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 7.33±0.70(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29349990

SNS-032 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2218 SNS-032 ≥98% (HPLC) 345627-80-7 5MG ₹9093 2022-06-14 Buy
Sigma-Aldrich(India) SML2218 SNS-032 ≥98% (HPLC) 345627-80-7 25MG ₹36707.58 2022-06-14 Buy
Product number Packaging Price Buy
SML2218 5MG ₹9093 Buy
SML2218 25MG ₹36707.58 Buy

SNS-032 Chemical Properties,Uses,Production

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.

Chemical Properties

Off-White Solid

Uses

SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.

SNS-032 Preparation Products And Raw materials

Raw materials

Preparation Products

SNS-032 Suppliers

Global( 162)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
ANHUI WITOP BIOTECH CO., LTD 58
Dideu Industries Group Limited 58

SNS-032 Spectrum

SNS-032(345627-80-7)1HNMR

345627-80-7(SNS-032)Related Search:

3,3-Dimethyl-1-butyne N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Y27632 (hydrochloride)
Alisertib (MLN8237) PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib
Hexahydroisonicotinamide 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID [5-(5-TERT-BUTYL-OXAZOL-2-YLMETHYLSULFANYL)-THIAZOL-2-YL]-AMIDE SNS-032
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BMS-3870032 N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide SNS-032 (BMS-387032) N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamid SNS-032, >=99% N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide BMS-387032 4-Piperidinecarboxamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)- N-(5-((5-Tert-Butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide 1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]- N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide(BMS-3870032) BMS-3870032 SNS0032(BMS-387032) SNS-032 BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032 CS-202 SNS 032; SNS032; SNS-032; BMS387032; BMS 387032; BMS-387032 SNS-032, 98.5%, a selective CDK2 inhibitor N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide USP/EP/BP N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thia... BMS-387032/SNS-032 N-(5-(((4-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)piperidine-4-carboxamide 345627-80-7 C17H24N4O2S2 Inhibitors Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9. Aromatics Heterocycles Intermediates & Fine Chemicals. Sulfur & Selenium Compounds Pharmaceuticals Inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.