ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >MLN-8237

MLN-8237

CAS No.: 1028486-01-2

Chemical Name:: MLN-8237

Synonyms: Alisertib;Alisertib (MLN8237);MLN8237 (Alisertib);CS-277;MLN-823;MLN-8237;MLN-8237; MLN 8237;MLN-8237 USP/EP/BP;13C,2H3]-Alisertib;ALIERTIB (MLN 8237)

CBNumber:: CB62510095

Molecular Formula:: C27H20ClFN4O4

Molecular Weight:: 518.92

MOL File:: 1028486-01-2.mol

Modify Date:: 2023/6/8 9:03:09

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MLN-8237 Properties

Boiling point	729.1±70.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 5 mg/ml)
form	solid
pka	4.07±0.10(Predicted)
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Signal word

Warning

Hazard statements

H320

Precautionary statements

P264-P305+P351+P338-P337+P313

NFPA 704

	0
1		0

MLN-8237 Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

An Aurora kinase inhibitor, used to treat patients with advanced solid tumors.

MLN-8237 Preparation Products And Raw materials

Raw materials

(1E,4E)-8-chloro-4-((diMethylaMino)Methylene)-1-(2-fluoro-6-Methoxyphenyl)-3,4-dihydrobenzo[c]azepin-5-one (5-CHLORO-2-IODOPHENYL) 2,6-DIFLUOROPHENYL METHANO CARBAMIC ACID, [3-[4-CHLORO-2-(2-FLUORO-6-METHOXYBENZOYL)PHENYL]-2-PROPYNYL]-, 1,1-DIMETHYLETHYL ESTER 4-Guanidino-2-methoxybenzoic Acid Hydrochloride (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE

2-AMINO-5-CHLORO-2',6'-DIFLUOROBENZOPHENONE Methyl 4-amino-2-methoxybenzoate

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Preparation Products

MLN-8237 Suppliers

Global( 184)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58

MLN-8237 Spectrum

MLN-8237(1028486-01-2)¹HNMR

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Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy- MLN-8237 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid alisertib (auroura A kinase inhibitor) Fluorocyclopentenylcytosine ALISERTIB (MLN8237);MLN 8237; MLN8237;MLN-8237 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido-[4,5-e]azepin-2-yl)amino)-2-meth MLN-823 MLN-8237 4-((9-chloro-7-(2-fluoro-6-Methoxyphenyl)-5H-benzo[c]pyriMido[4,5-e]azepin-2-yl)aMino)-2-Methoxybenzoic acid 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido-[4,5-e]azepin-2-yl)amino)-2-methoxy MLN 8237 (Contain 10% DMSO) MLN-8237; MLN 8237 CS-277 ALIERTIB (MLN 8237) ALISERTIB;MLN 8237;MLN-8237 MLN-8237 USP/EP/BP MLN8237 (Alisertib) Alisertib Alisertib (MLN8237) 13C2,2H3,15N2]-Alisertib 13C,2H3]-Alisertib MLN8237 Alisertib MLN-8237 arrest,myeloma,cytotoxicity,MLN-8237,spindle,Alisertib,inhibit,mitotic,Autophagy,Aurora Kinase,cancer,multiple,Inhibitor,MLN8237,cell-cycle,Apoptosis 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido-[4,5-e]azepin-2-yl)amino)-2-methoxy MLN 8237 (Contain 10% DMSO) 1028486-01-2 C27H20ClFN4O4 Inhibitor Inhibitors Intermediates & Fine Chemicals Pharmaceuticals API