ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

CAS No.: 722544-51-6

Chemical Name:: 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

Synonyms: Barasertib;AZD-1152HQPA;Barasertib (AZD1152-HQPA);AZD-2811;AZD1152-HQPA;CS-41;INH 34;AZD1152 HPQA;Barasertib-HQPA;Defosbarasertib

CBNumber:: CB01512456

Molecular Formula:: C26H30FN7O3

Molecular Weight:: 507.56

MOL File:: 722544-51-6.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 16:42:00

Request For Quotation

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Properties

Boiling point	796.7±60.0 °C(Predicted)
Density	1.359±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >15mg/mL
pka	13.07±0.10(Predicted)
form	powder
color	white to beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey	QYZOGCMHVIGURT-UHFFFAOYSA-N
CAS DataBase Reference	722544-51-6

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
WGK Germany	3

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0268	AZD1152-HQPA ≥98% (HPLC)	722544-51-6	10MG	₹11677.2	2022-06-14	Buy
Sigma-Aldrich(India)	SML0268	AZD1152-HQPA ≥98% (HPLC)	722544-51-6	50MG	₹47208.3	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0268	10MG	₹11677.2	Buy
SML0268	50MG	₹47208.3	Buy

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Chemical Properties,Uses,Production

Uses

AZD1152-HQPA is a a highly selective inhibitor of aurora-B kinase. AZD1152-HQPA has been shown to inhibit osteosarcoma cell line U2-OS cells proliferation. AZD1152-HQPA was also shown to be an effective apoptosis-inducing agent in acute myeloid leukemia cell lines and primary acute myeloid leukemia cultures.

Biochem/physiol Actions

AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines.

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Suppliers

Global( 143)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26063	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Spectrum

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-(722544-51-6)MS 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-(722544-51-6)¹HNMR

722544-51-6(1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-)Related Search:

METHOPRENE ACID N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) NORFLUOXETINE HYDROCHLORIDE Ethyl acetate Ethylhexylglycerin

2-HYDROXYETHYLUREA Decamethylcyclopentasiloxane 4'-Hydroxyacetophenone Hydroxyethyl Cellulose ZM 447439

MK-2206 2HCl Alisertib (MLN8237) Tozasertib BI 2536 MLN8054

Barasertib (AZD1152-HQPA)

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INH 34 2-(3-(7-(3-(Ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-ylamino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide AZD1152-HQPA(Barasertib) 2-[5-(7-{3-[Ethyl-(2-hydroxy-ethyl)-aMino]-propoxy}-quinazolin-4-ylaMino)-2H-pyr 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- 2-[5-(7-{3-[ETHYL-(2-HYDROXY-ETHYL)-AMINO]-PROPOXY}-QUINAZOLIN-4-YLAMINO)-2H-PYRAZOL-3-YL]-N-(3-FLUORO-PHENYL)-ACETAMIDE AZD1152 HPQA 2-(5-(7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-ylamino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide AZD1152-HQPA AZD1152-HQPA 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide 3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide Barasertib, >=98% BARASERTIB (AZD1152-HQPA);AZD1152; AZD 1152 2-(5-((7-(3-(Ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-3-yl)-N-(3-f AZD-2811; AZD 2811; AZD2811; AZD-1152HQPA; AZD 1152HQPA; AZD1152HQPA; AZD1152 HQPA; AZD1152-HQPA; AZD1152HQPA. CS-41 AZD1152; AZD-1152 Barasertib-HQPA AZD1152-HQPA;BARASERTIB;AZD1152;AZD 1152;INH 34 1H-Pyrazole-3-acetamide AZD1152-HQPA|AZD2811 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- USP/EP/BP Barasertib ( INH-34 Barasertib (AZD1152-HQPA|AZD2811) Barasertib Barasertib (AZD1152-HQPA) AZD-2811 AZD1152-HQPA AZD-1152HQPA AZD1152-HQPA Aurora B kinase inhibitor ab142049 Defosbarasertib 722544-51-6 C26H30FN7O3 Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators API intermediates Inhibitor