ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >ZM 447439
ZM 447439
- CAS No.
- 331771-20-1
- Chemical Name:
- ZM 447439
- Synonyms
- CS-77;ZM 447439;ZM 447439, >=98%;ZM-447439;ZM447439;ZM 447439 USP/EP/BP;Aurora Kinase Inhibitor VI ZM447439 ZM-447439;Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem;N-(4-((6-Methoxy-7-(3-Morpholinopropoxy)quinazolin-4-yl)aMino)phenyl)benzaMide;N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE;BenzaMide, N-[4-[[6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]phenyl]-
- CBNumber:
- CB8849467
- Molecular Formula:
- C29H31N5O4
- Molecular Weight:
- 513.59
- MOL File:
- 331771-20-1.mol
- Modify Date:
- 2024/11/14 20:10:21
| Melting point | 117-120°C |
|---|---|
| Boiling point | 639.7±55.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | White solid |
| pka | 13.01±0.70(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase? as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| NFPA 704 |
|
ZM 447439 price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 189410 | Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation | 331771-20-1 | 5MG | ₹15469.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 189410 | Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecul | 331771-20-1 | 5MG | ₹15469.99 | 2022-06-14 | Buy |
ZM 447439 Chemical Properties,Uses,Production
Description
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively). It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 μM). ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis. Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-
Chemical Properties
Pale Yellow Solid
ZM 447439 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 141)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32951 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32080 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22883 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | China | 4128 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9984 | 58 | Inquiry |
331771-20-1(ZM 447439)Related Search:
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N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE
ZM 447439
N-(4-((6-Methoxy-7-(3-Morpholinopropoxy)quinazolin-4-yl)aMino)phenyl)benzaMide
BenzaMide, N-[4-[[6-Methoxy-7-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]phenyl]-
ZM-447439;ZM447439
ZM 447439, >=98%
Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem
CS-77
ZM 447439 USP/EP/BP
Aurora Kinase Inhibitor VI ZM447439 ZM-447439
331771-20-1
C29H31N5O4
Inhibitor
Aromatics
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals