ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >Raf inhibitors >ZM 336372

ZM 336372

ZM 336372 Structure
CAS No.
208260-29-1
Chemical Name:
ZM 336372
Synonyms
CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372; ZM-336372;ZINC00581684;ZM 336372 - CAS 208260-29-1 - Calbiochem;N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
CBNumber:
CB6428631
Molecular Formula:
C23H23N3O3
Molecular Weight:
389.45
MOL File:
208260-29-1.mol
MSDS File:
SDS
Modify Date:
2023/9/4 16:42:00

ZM 336372 Properties

Boiling point 484.4±45.0 °C(Predicted)
Density 1.298
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: >5mg/mL (warmed)
pka 8.31±0.15(Predicted)
form powder
color white to beige
Sensitive Light Sensitive
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317-H413
Precautionary statements  P261-P272-P273-P280-P302+P352-P333+P313
WGK Germany  3
HS Code  2924297099
NFPA 704
0
2 0

ZM 336372 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 692000 ZM 336372 - CAS 208260-29-1 - Calbiochem A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC?? = 70 nM). 208260-29-1 1MG ₹22650 2022-06-14 Buy
Product number Packaging Price Buy
692000 1MG ₹22650 Buy

ZM 336372 Chemical Properties,Uses,Production

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

ZM 336372 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 143)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry

ZM 336372 Spectrum

N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE ZM 336372 Zinc00581684 3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE 3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]- ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide ZM 336372, >=98% ZM 336372;ZM-336372 ZM 336372 - CAS 208260-29-1 - Calbiochem CS-44 ZM 336372; ZM-336372;ZINC00581684 ZM 336372 USP/EP/BP 208260-29-1 08260-29-1 C23H23N3O3 Inhibitors MAPK A potent and specific inhibitor of the protein kinase c-Raf. Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals