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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >mTOR inhibitors >ZOTAROLIMUS

ZOTAROLIMUS

ZOTAROLIMUS Structure
CAS No.
221877-54-9
Chemical Name:
ZOTAROLIMUS
Synonyms
ABT 578;CS-1162;A 179578;Resolute;ZOTAROLIMUS;ZotaroliMus API;Unii-H4gxr80ize;Zotarolimus, >ZotaroliMus, >90%;ZotaroliMus(ABT-578)
CBNumber:
CB21011766
Molecular Formula:
C52H79N5O12
Molecular Weight:
966.21
MOL File:
221877-54-9.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:30:58
Request For Quotation

ZOTAROLIMUS Properties

Melting point 100-105°C
Boiling point 1016.2±75.0 °C(Predicted)
Density 1.25
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMSO, Methanol (Slightly)
form Solid
pka 10.40±0.70(Predicted)
color White to Pale Yellow

SAFETY

Risk and Safety Statements

HS Code  29349990

ZOTAROLIMUS Chemical Properties,Uses,Production

Description

Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin . It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED50 = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 μg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.

Chemical Properties

Pale Yellow Solid

Uses

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.

ZOTAROLIMUS Preparation Products And Raw materials

Raw materials

Preparation Products

ZOTAROLIMUS Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9343 55 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24099 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Hangzhou FandaChem Co.,Ltd. 55
Chongqing Chemdad Co., Ltd 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
BOC Sciences 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58

ZOTAROLIMUS Spectrum

ZOTAROLIMUS(221877-54-9)MS

221877-54-9(ZOTAROLIMUS)Related Search:

AZD 3759 (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol Zonisamide Z-NLE-OH ZM 336372
ZM 39923 HYDROCHLORIDE Z-NVA-OH Z-N-Methyl-D-valine Z-ORN(BOC)-OH ZPCK
Tepotinib Saracatinib Dasatinib Trametinib Epothilone B
Ruxolitinib ZOSUQUIDAR TRIHYSROCHLORIDE Rapamycin
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ZOTAROLIMUS (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin A 179578 ABT 578 Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)- Unii-H4gxr80ize ZotaroliMus, >90% 42-(1-Tetrazolyl)rapamycin Resolute ZotaroliMus API 42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute Zotarolimus A 179578 ZotaroliMus(ABT-578) ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578 CS-1162 Zotarolimus, > ZOTAROLIMUS USP/EP/BP ZOTAROLIMUS Impurities 221877-54-9 C52H79N5O12 Inhibitors Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals