Epothilone B
- CAS No.
- 152044-54-7
- Chemical Name:
- Epothilone B
- Synonyms
- CS-556;EPO 906A;atupilone;EPOTHILONE;Patupilone;Ebomycin B;Epothilon B;Epothilone B;Oncology API;Epothilone B, >=98%
- CBNumber:
- CB0972824
- Molecular Formula:
- C27H41NO6S
- Molecular Weight:
- 507.68
- MOL File:
- 152044-54-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 95-97°C |
|---|---|
| alpha | D21 -35° (c = 0.7 in methanol) |
| Boiling point | 680.2±55.0 °C(Predicted) |
| Density | 1.136 |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml). |
| form | White to off-white solid |
| pka | 13.57±0.70(Predicted) |
| color | colorless |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
| CAS DataBase Reference | 152044-54-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS09,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H310-H341-H360-H372-H315-H317-H410-H300 | |||||||||
| Precautionary statements | P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
Epothilone B price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E2656 | (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) | 152044-54-7 | 1MG | ₹5260.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E2656 | (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) | 152044-54-7 | 5MG | ₹15988.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 325001 | Epothilone B, Synthetic A structural analog of Epothilone A with similar biological properties. | 152044-54-7 | 1MG | ₹14970 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E1378 | Epothilone B | 152044-54-7 | 5MG | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E1378 | Epothilone B | 152044-54-7 | 25MG | ₹22900 | 2022-05-26 | Buy |
Epothilone B Chemical Properties,Uses,Production
Chemical Properties
White Powder
Uses
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Definition
ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).
General Description
Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules. Epothilone B is used to treat metastatic breast cancer (MBC).
Biological Activity
Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .
Side effects
Patupilone is naturally occurring epothilone B. The major dose-limiting adverse reaction to patupilone is diarrhea, rather than neuropathy. Other significant adverse reactions include fatigue and nausea. In phase I/II studies, severe diarrhea was reported in 14–19% of patients. Hematological toxicity appears to be minimal. Grade 3 peripheral neuropathy was the dose-limiting adverse reaction in one phase I study, along with grade 3 diarrhea[3].
References
1) Goodin et al. (2004), Epothilones: mechanism of action and biologic activity; J. Clin. Oncol., 22 2015
2) Bollag et al. (1995), Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action; Cancer Res., 55 2325.
3) Lipp, H. and J. Hartmann. “Chapter 45 - Cytostatic and cytotoxic drugs.”Side Effects of Drugs Annual (2011):935-962.
Epothilone B Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shanghai Minbiotech Co., Ltd. | +8617315815539 | CHINA | 129 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5840 | 58 | Inquiry |
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