Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >API >Antineoplastic agents >Natural sources of antineoplastic >Epothilone D

Epothilone D

Epothilone D Structure
CAS No.
189453-10-9
Chemical Name:
Epothilone D
Synonyms
Epo D;KOS 862;CS-1161;Ebomycin;NSC 703147;Epothilone D;12,13-Deoxyepo;Desoxyepothilone B;13-Desoxyepothilone B;Epothilone D (KOS-862)
CBNumber:
CB41214330
Molecular Formula:
C27H41NO5S
Molecular Weight:
491.68
MOL File:
189453-10-9.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:13
Request For Quotation

Epothilone D Properties

Melting point 63-66°C
alpha D22 -61.3° (c = 2.5 in methanol)
Boiling point 663.7±55.0 °C(Predicted)
Density 1.084±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Soluble in DMSO
form solid
pka 13.47±0.70(Predicted)
color white to off-white

Epothilone D Chemical Properties,Uses,Production

Description

Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions. They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models. Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice. Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice. Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss. Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.

Chemical Properties

White Foam

Definition

ChEBI: An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.

Epothilone D Preparation Products And Raw materials

Raw materials

Preparation Products

Epothilone B

Epothilone D Suppliers

Global( 129)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16221 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32715 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 15093356674; China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26721 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Shanghai Daken Advanced Materials Co.,Ltd 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Dideu Industries Group Limited 58

189453-10-9(Epothilone D)Related Search:

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Paclitaxel Tigecycline MITHRAMYCIN A Abiraterone
Daptomycin Geldanamycin RIFAMYCIN SV Vinorelbine tartrate Epothilone B
Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Epothilone A epothilone E BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID (αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE
chevron_left

1of4

chevron_right
Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl -16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S-(4R*,7S,8R*,9R*,1 3Z,16R*(E)))- (3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione Epothilone D Desoxyepothilone B (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentaMethyl-16-[(1E)-1-Methyl-2-(2-Methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione 12,13-Desoxyepothilone B Epo D KOS 862 NSC 703147 12;13-DESOXYEPOTHILONE B; DESOXYEPOTHILONE B; KOS 862 13-Desoxyepothilone B CS-1161 Epothilone D (KOS-862) 12,13-Deoxyepo Paclitaxel Impurity 110 Epothilone D USP/EP/BP Ebomycin 189453-10-9 Inhibitors Chiral Reagents Intermediates & Fine Chemicals Anti-cancer&immunity Pharmaceuticals Sulfur & Selenium Compounds API