4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole

CAS No.: 308357-81-5

Chemical Name:: 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole

Synonyms: Paclitaxel Impurity 74;4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-8-(phenylsulfonyl)-1,5-undecadi;4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole;Thiazole, 4-[(1E,3S,5Z,10S)-3,11-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-8-(phenylsulfonyl)-1,5-undecadien-1-yl]-2-methyl-

CBNumber:: CB01175808

Molecular Formula:: C36H61NO4S2Si2

Molecular Weight:: 692.17

MOL File:: 308357-81-5.mol

Modify Date:: 2023/5/25 8:31:34

Request For Quotation

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Properties

Boiling point	691.6±55.0 °C(Predicted)
Density	1.027±0.06 g/cm3(Predicted)
solubility	Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
pka	2.72±0.10(Predicted)
form	Oil
color	Colourless
CAS DataBase Reference	308357-81-5

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Chemical Properties,Uses,Production

Chemical Properties

Colourless Oil

Uses

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Preparation Products And Raw materials

Raw materials

Thiazole, 4-[(1E,3S,5Z)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-iodo-2,6-dimethyl-1,5-heptadien-1-yl]-2-methyl- (3S)-4-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-3-METHYLBUTYL PHENYL SULFONE (-)-(3S)-3-([TERT-BUTYL(DIMETHYL)SILYL]OXY)DIHYDROFURAN-2(3H)-ONE

Preparation Products

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole Suppliers

Global( 12)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Medical Isotopes	1-(603) 635-1722	United States	6185	68	Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	China	15848	69	Inquiry
Toronto Research Chemicals	+1 (416) 665-9696	Canada	6088	71	Inquiry
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	China	96815	76	Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	China	56068	58	Inquiry
Carbosynth	+86 512 6260 5585	United Kingdom	6018	58	Inquiry
Medical Isotopes, Inc	（603）635-2255	United States	3183	58	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry

Supplier	Advantage
SynZeal Research Pvt Ltd	58
Medical Isotopes	68
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Toronto Research Chemicals	71
J & K SCIENTIFIC LTD.	76
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Carbosynth	58
Medical Isotopes, Inc	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	58

308357-81-5(4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole)Related Search:

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(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE Epothilone B 4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID 2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel

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4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-8-(phenylsulfonyl)-1,5-undecadi Thiazole, 4-[(1E,3S,5Z,10S)-3,11-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-8-(phenylsulfonyl)-1,5-undecadien-1-yl]-2-methyl- Paclitaxel Impurity 74 308357-81-5 C36H61NO4S2Si2 Chiral Reagents