4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole
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4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 속성
- 끓는 점
- 691.6±55.0 °C(Predicted)
- 밀도
- 1.027±0.06 g/cm3(Predicted)
- 용해도
- 클로로포름, 디클로로메탄, 에탄올, 에틸아세테이트, 메탄올, 톨루엔에 용해됨
- 산도 계수 (pKa)
- 2.72±0.10(Predicted)
- 물리적 상태
- 기름
- 색상
- 무색
- CAS 데이터베이스
- 308357-81-5
안전
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole C화학적 특성, 용도, 생산
화학적 성질
Colourless Oil용도
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 준비 용품 및 원자재
원자재
Thiazole, 4-[(1E,3S,5Z)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-iodo-2,6-dimethyl-1,5-heptadien-1-yl]-2-methyl-
(3S)-4-([tert-부틸(디메틸)실릴]옥시)-3-메틸부틸페닐설폰
(-)-(3S)-3-([TERT-BUTYL(DIMETHYL)SILYL]OXY)DIHYDROFURAN-2(3H)-ONE
준비 용품
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 공급 업체
글로벌( 12)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94658 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32344 | 50 |
S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 |
China | 4505 | 50 | |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 |
sales@rrkchem.com | China | 56086 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
Carbosynth | -- |
sales@carbosynth.com | United Kingdom | 6018 | 58 |
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 관련 검색:
(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
7-Xylosyl-10-deacetyltaxol
Paclitaxel Impurity 9
N-Desbenzoyl-N-tert-butoxycarbonyl-N,O-isopropylidene-3a€-p-O-benzyl-6,7-dehydro Paclitaxel
2'-O-(Benzyloxycarbonyl) Taxol
(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid
6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE
Epothilone B
4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID
2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel
(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Docetaxel-D9
Paclitaxel EP Impurity I
(4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester
13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(triethylsilyl) Baccatin III
DHA-paclitaxel
2',7-Bis-O-(Triethylsilyl) 10-Desacetyl Paclitaxel