Geldanamycin
- CAS No.
- 30562-34-6
- Chemical Name:
- Geldanamycin
- Synonyms
- GA;Streptomyces hygroscopicus;[(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate;(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione;CS-503;nsc122750;CP-122634;NSC 212518;Geldamycin;GELDANAMYCIN
- CBNumber:
- CB8462842
- Molecular Formula:
- C29H40N2O9
- Molecular Weight:
- 560.64
- MOL File:
- 30562-34-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/23 13:21:54
| Melting point | 255 °C |
|---|---|
| Boiling point | 627.87°C (rough estimate) |
| Density | 1.2443 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| Flash point | 87℃ |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | 8.42±0.70(Predicted) |
| color | yellow to orange |
| biological source | Streptomyces hygroscopicus |
| λmax | 305nm(MeOH)(lit.) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
| CAS DataBase Reference | 30562-34-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H227 | |||||||||
| Precautionary statements | P210e-P280a-P370+P378a-P403+P235-P501a | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-27-36/37/39-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | LX8920000 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
Geldanamycin price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1278 | Geldanamycin Ready Made Solution 1?mg/mL, from Streptomyces hygroscopicus | 30562-34-6 | 1ML | ₹17383.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G3381 | Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder | 30562-34-6 | 1MG | ₹86123.7 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0334 | Geldanamycin | 30562-34-6 | 10MG | ₹8800 | 2022-05-26 | Buy |
| SRL | 23813 | Geldanamycin (GLD), 98% | 30562-34-6 | 5mg | ₹65210 | 2022-05-26 | Buy |
Geldanamycin Chemical Properties,Uses,Production
Description
Geldanamycin from Streptomyces hygroscopicus.
Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.
Chemical Properties
Yellow to Orange Powder
Uses
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Definition
ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
General Description
Chemical structure: benzenoid
Biological Activity
Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.
Geldanamycin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4315 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6088 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2332 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 526 | 58 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
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