Geldanamycin
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Geldanamycin 속성
- 녹는점
- 255 °C
- 끓는 점
- 627.87°C (rough estimate)
- 밀도
- 1.2443 (rough estimate)
- 굴절률
- 1.5800 (estimate)
- 인화점
- 87℃
- 저장 조건
- -20°C
- 용해도
- DMSO: 용해될 수 있다
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.42±0.70(Predicted)
- 색상
- 노란색에서 주황색으로
- 최대 파장(λmax)
- 305nm(MeOH)(lit.)
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 30562-34-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-27-36/37/39-24/25 | ||
WGK 독일 | 2 | ||
RTECS 번호 | LX8920000 | ||
HS 번호 | 29419090 |
Geldanamycin C화학적 특성, 용도, 생산
개요
Geldanamycin from Streptomyces hygroscopicus.Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.
화학적 성질
Yellow to Orange Powder용도
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.정의
ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.일반 설명
Chemical structure: benzenoid생물학적 활성
Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.Geldanamycin 준비 용품 및 원자재
원자재
준비 용품
Geldanamycin 공급 업체
글로벌( 317)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Hebei shuoxi biotechnology co. LTD | +8613081092107 |
CHINA | 968 | 58 | |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Geldanamycin 관련 검색:
메틸-파라-벤조퀴논
CHLOROPHOSPHONAZO III
Retaspimycin
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
17-AAG
3-HEXENE-1 6-DIOLE
2-METHOXY-3-METHYL-[1,4]BENZOQUINONE
2-methoxyethyl carbamate
herbimycin B
N-DECYL ACRYLAMIDE
N-DECYL METHACRYLAMIDE
17-Demethoxy-17-(allylamino-d5)geldanamycin,17-(Allylamino-d5) Geldanamycin,17-Demethoxy-17-(2-propenylamino-d5)geldanamycin
17-Amino Geldanamycin-13C,15N2
17-Amino Geldanamycin
17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN
Geldanamycin
GELDANAMYCIN 95%
17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN, HCL,17-N,N-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXY-GELDANAMYCIN, HCL