17-AAG
- CAS No.
- 75747-14-7
- Chemical Name:
- 17-AAG
- Synonyms
- 17-AG;17-AAG;17-AGG;Gld-36;CS-480;KOS 953;CP 127374;TELATINIB;Tiratinib;NSC-330507
- CBNumber:
- CB1195912
- Molecular Formula:
- C31H43N3O8
- Molecular Weight:
- 585.69
- MOL File:
- 75747-14-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 9:28:36
| Melting point | 201-203°C |
|---|---|
| Boiling point | 797.8±60.0 °C(Predicted) |
| Density | 1.21 |
| RTECS | LX8932000 |
| Flash point | >110°(230°F) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 8.62±0.70(Predicted) |
| color | Purple or dark red |
| Water Solubility | Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 75747-14-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H317 |
| Precautionary statements | P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| HS Code | 29419090 |
17-AAG price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8476 | 17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid | 75747-14-7 | 500μG | ₹31284.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 100068 | 17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus. | 75747-14-7 | 500μG | ₹31190 | 2022-06-14 | Buy |
| ALFA India | ALF-J66960-MC | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 100mg | ₹27694 | 2022-05-26 | Buy |
| ALFA India | ALF-J66960-MB | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 25mg | ₹18880 | 2022-05-26 | Buy |
| ALFA India | ALF-J66960-EX3 | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 200mg | ₹32407 | 2022-05-26 | Buy |
17-AAG Chemical Properties,Uses,Production
Chemical Properties
Dark Purple Solid
Uses
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Definition
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, t induces apoptosis and displays antitumour effects.
General Description
Chemical structure: benzenoid
Biological Activity
Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Subsequently inhibits the activity of oncogenic proteins such as p185 erbB-2 (IC 50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo .
17-AAG Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 224)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9332 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 990 | 58 | Inquiry |
Related articles
- 17-AAG: Antitumour Activity and Its Molecular Mechanisms
- 17-AAG exhibits potent antitumor effects across various cancers, with reduced toxicity, targeting multiple pathways for promis....
- Apr 23，2024
- What is 17-AAG？
- 17-AAG is an Hsp90 inhibitor. This compound is a synthetic analog of geldanamycin, an antibiotic first purified in 1970 from S....
- Oct 20，2023
75747-14-7(17-AAG)Related Search:
GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-
CP 127374
ALLYLAMINOGELDANAMYCIN
NSC-330507
17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN
17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN
17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN
17-ALLYLAMINOGELDANAMYCIN
17-AG
17-AGG
17-AAG
17-DEMETHOXY-17-(2-PROPENYLAMINO)-GELDANAMYCIN
17-DEMETHOXY-17-ALLYLAMINO GELDANAMYCIN
17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN (17-AAG)
17-AAG, CP 127374
17-(Allylamino)-17-desmethylgeldanamycin
KOS 953
Tanespimycin
TELATINIB
17-ALLYLAMINO-17-DIMETHOXYGELDANAMYCIN (17-AAG)
17-AAG,17AAG
17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507
Geldanamycin, 17-allylamino-17-demethoxy-
Geldanamycin, des-o-methyl-17-allylamino-
Gld-36
17-AAG(GeldanaMycin)
Telatinib(TanespiMycin,KOS-953, 17-AAG,NSC 330507)
17-AAG (KOS953)
17-AAG (TanespiMycin)
17AAG (17-(AllylaMino)-17-deMethoxy- geldanaMycin)
17-demethoxy-17-(2-propenylamino)- [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
CP127374,NSC-330507
Telatinib
17-Demethoxy-17-allylaminogeldanamycin
Telatinib/ 17-AAG
Tanespimycin, >=98%
Tanespimycin (17-AAG)
17 AAG (Tanespimyciin)
CS-480
Geldanamycin Impurity 1(17-Allylamino-17-Demethoxygeldanamycin)
Geldanamycin 17-Allylamino
17-AAG USP/EP/BP
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
[(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
anespimycin
Tiratinib
75747-14-7
C31H43N3O8
Antibiotics
Antibiotics A to Z
Antibiotics A-F
BioChemical
antibiotic
Amines
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Heat Shock Protein 90