17-AAG
![17-AAG Structure](CAS/GIF/75747-14-7.gif)
- CAS No.
- 75747-14-7
- Chemical Name:
- 17-AAG
- Synonyms
- 17-AG;17-AAG;17-AGG;Gld-36;CS-480;KOS 953;CP 127374;TELATINIB;Tiratinib;NSC-330507
- CBNumber:
- CB1195912
- Molecular Formula:
- C31H43N3O8
- Molecular Weight:
- 585.69
- MOL File:
- 75747-14-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 9:28:36
Melting point | 201-203°C |
---|---|
Boiling point | 797.8±60.0 °C(Predicted) |
Density | 1.21 |
RTECS | LX8932000 |
Flash point | >110°(230°F) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO: soluble |
form | solid |
pka | 8.62±0.70(Predicted) |
color | Purple or dark red |
Water Solubility | Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water |
Sensitive | Light Sensitive |
Stability | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 75747-14-7 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H317 |
Precautionary statements | P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-24/25-36-26 |
WGK Germany | 3 |
HS Code | 29419090 |
17-AAG price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | A8476 | 17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid | 75747-14-7 | 500μG | ₹31284.25 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 100068 | 17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus. | 75747-14-7 | 500μG | ₹31190 | 2022-06-14 | Buy |
ALFA India | ALF-J66960-MC | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 100mg | ₹27694 | 2022-05-26 | Buy |
ALFA India | ALF-J66960-MB | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 25mg | ₹18880 | 2022-05-26 | Buy |
ALFA India | ALF-J66960-EX3 | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 75747-14-7 | 200mg | ₹32407 | 2022-05-26 | Buy |
17-AAG Chemical Properties,Uses,Production
Chemical Properties
Dark Purple Solid
Uses
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Definition
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, t induces apoptosis and displays antitumour effects.
General Description
Chemical structure: benzenoid
Biological Activity
Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Subsequently inhibits the activity of oncogenic proteins such as p185 erbB-2 (IC 50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo .
17-AAG Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9332 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 990 | 58 | Inquiry |
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