Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Organic Chemistry >Organometallic compounds >Organolithium >Lithium diisopropylamide

Lithium diisopropylamide

Lithium diisopropylamide Structure
CAS No.
4111-54-0
Chemical Name:
Lithium diisopropylamide
Synonyms
LDA;Lithium salt;LITHIUM DIISOPROPYLAMINE;lithium,di(propan-2-yl)azanide;lithium diisopropylamide (LDA);ithium diisopropyL;DIIS;LDA THF COMPLEX;iisopropylamide;Kseal,reagent grade
CBNumber:
CB6677718
Molecular Formula:
C6H16LiN
Molecular Weight:
109.14
MOL File:
4111-54-0.mol
MSDS File:
SDS
Modify Date:
2024/7/4 21:45:01
Request For Quotation

Lithium diisopropylamide Properties

Melting point decomposes [MER06]
Boiling point 65 °C
Density 0.864 g/mL at 25 °C (lit.)
vapor density >1 (vs air)
Flash point 91 °F
storage temp. 2-8°C
solubility soluble in ethyl ether; insoluble in hydrocarbon solvents
form liquid
color brown
Water Solubility decomposes
Sensitive Air & Moisture Sensitive
Merck 14,3196
BRN 3655042
CAS DataBase Reference 4111-54-0(CAS DataBase Reference)
EPA Substance Registry System 2-Propanamine, N-(1-methylethyl)-, lithium salt (4111-54-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS05
Signal word  Danger
Hazard statements  H250-H314
Precautionary statements  P231+P232-P260-P280-P303+P361+P353-P305+P351+P338-P370+P378
Hazard Codes  C,N,F
Risk Statements  14-17-34-67-65-51/53-35-19-15-11-50/53-14/15-10-40-23/24/25-62-63-37-48/20
Safety Statements  26-36/37/39-43-45-60-61-62-8-16-23-33-27
RIDADR  UN 3399 4.3/PG 2
WGK Germany  3
F  1-10
TSCA  Yes
HazardClass  4.2
PackingGroup  I
HS Code  29211990

Lithium diisopropylamide price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 774766 Lithium diisopropylamide solution 1.0?M in THF/hexanes 4111-54-0 100ML ₹7155.33 2022-06-14 Buy
Sigma-Aldrich(India) 774766 Lithium diisopropylamide solution 1.0?M in THF/hexanes 4111-54-0 4X25ML ₹7956.38 2022-06-14 Buy
Sigma-Aldrich(India) 361798 Lithium diisopropylamide solution 2.0?M in THF/heptane/ethylbenzene 4111-54-0 100ML ₹7274.4 2022-06-14 Buy
Sigma-Aldrich(India) 774766 Lithium diisopropylamide solution 1.0?M in THF/hexanes 4111-54-0 500ML ₹19853.05 2022-06-14 Buy
Sigma-Aldrich(India) 361798 Lithium diisopropylamide solution 2.0?M in THF/heptane/ethylbenzene 4111-54-0 4X25ML ₹8963.1 2022-06-14 Buy
Product number Packaging Price Buy
774766 100ML ₹7155.33 Buy
774766 4X25ML ₹7956.38 Buy
361798 100ML ₹7274.4 Buy
774766 500ML ₹19853.05 Buy
361798 4X25ML ₹8963.1 Buy

Lithium diisopropylamide Chemical Properties,Uses,Production

Chemical Properties

Lithium diisopropylamide (LDA) is a white pyrophoric powder. Freshly prepared, it is soluble in hydrocarbons (in hexane about 10 %), but it tends to precipitate irreversibly from solution as a polymer on heating or prolonged storage. In ethers the solubility is much higher, but with the exception of tetrahydropyran, LDA is decomposed at a rate depending on the ether, concentration, and temperature.
Lithium diisopropylamide can be conveniently prepared from butyllithium and diisopropylamine or purchased as a 2 mol/L (25 %) solution in THF and a mixture of various hydrocarbons. Although LDA is unstable in pure THF (at room temperature a 25% solution loses about 1% of its activity per day), the commercially available compositions containing only a limited amount of THF are satisfactory stable for technical applications.

Chemical Properties

dark yellow to orange or dark red-brown solution. Lithium Diisopropylamide (LDA) [4111- 54-0], LiN(CH(CH3)2)2, Mr 107.14 is a white pyrophoric powder. Freshly prepared, it is soluble in hydrocarbons (in hexane about 10 %), but it tends to precipitate irreversibly from solution as a polymer on heating or prolonged storage. In ethers the solubility is much higher, but with the exception of tetrahydropyran, LDA is decomposed at a rate depending on the ether, concentration, and temperature.

Uses

Lithium diisopropylamide is a sterically hindered nonnucleophilic strong base used for selective deprotonations, especially for the production of kinetic enolates (i.e., the thermodynamically less favored isomer) and (hetero-)aromatic carbanions. In the production of the serum lipid regulating agent Gemfibrozil one key intermediate is formed by quenching an ester enolate with 1-bromo-3-chloropropane.
Lithium diisopropylamide

General Description

This material is in a solution of THF/Hexanes (ca. 1:7 ratio, respectively)

Purification Methods

It is purified by refluxing over Na wire or NaH for 30minutes and then distilled into a receiver under N2. Because of the low boiling point of the amine, a dispersion of NaH in mineral oil can be used directly in this purification without prior removal of the oil. It is HIGHLY FLAMMABLE, and is decomposed by air and moisture. [Wittig & Hesse Org Synth 50 69 1970, Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]

Lithium diisopropylamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-FLUORO-2-IODOPYRIDINE-4-CARBOXYLIC ACID Ethyl 2-oxocyclopentylacetate 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE 2-Chloro-4-iodopyridine-3-carboxaldehyde 5-AMINO-2-METHOXY-ISONICOTINIC ACID
1-(2,6-DIFLUOROPYRIDIN-3-YL)PROPAN-1-ONE Ethyl 3-furancarboxylate 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID 4-Chloronicotinic acid
3-Bromothiophene-2-carbaldehyde 3-BROMOTHIOPHENE-2-CARBONYL CHLORIDE 3-FLUOROQUINOLINE-4-CARBOXYLIC ACID 3-Chlorothiophene-2-carboxylic acid 1H-Azepine-3-carboxylicacid,hexahydro-,methylester(9CI)
2-Fluoro-3-pyridylboronic acid 3-Chlorothiophene-2-carbonyl chloride Rimonabant hydrochloride 3-BROMOTHIOPHENE-2-CARBOXAMIDE 5-FLUORO-2-METHOXYPYRIDINE-4-BORONIC ACID
2-Methoxypyridine-3-boronic acid (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL 2-(4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)ETHANAMINE 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBALDEHYDE 3-FURANMETHANOL
5-BROMO-2-FLUOROPYRIDINE-3-CARBALDEHYDE ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBALDEHYDE 3,5-DIFLUOROPYRIDINE-4-CARBALDEHYDE
chevron_left

1of6

chevron_right

Lithium diisopropylamide Suppliers

Global( 395)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Almas Life Sciences +919441456585 Hyderabad, India 54 58 Inquiry
VASISTA LIFE SCIENCES PRIVATE LIMITED +91-04029554774 +91-9010855544 Hyderabad, India 153 58 Inquiry
Oceanic Pharmachem Pvt Ltd +91-91-2242128600 +91-2242128600 Maharashtra, India 33 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Ortin Laboratories Limited +91-9241566560 +91-9241566560 Hyderabad, India 31 58 Inquiry
FMC India Private Limited Karnataka, India 16 58 Inquiry
Organo Metallics +91-9391016448 +91-9705345345 Telangana, India 32 58 Inquiry
Spectrochem Private Limited 08048372608Ext 246 Maharashtra, India 1056 58 Inquiry
Symax Fine Chemicals 08068442240Ext 881 Hyderabad, India 51 58 Inquiry
Vasista Life Sciences +91 40-23770104 Hyderabad, India 21 58 Inquiry
Supplier Advantage
Almas Life Sciences 58
VASISTA LIFE SCIENCES PRIVATE LIMITED 58
Oceanic Pharmachem Pvt Ltd 58
JSK Chemicals 58
Ortin Laboratories Limited 58
FMC India Private Limited 58
Organo Metallics 58
Spectrochem Private Limited 58
Symax Fine Chemicals 58
Vasista Life Sciences 58

Related articles

  • Lithium diisopropylamide-LDA
  • Freshly prepared LDA has varying stability, being most stable in alkanes and 1:1 alkanes:THF. Homemade LDA should be stored co....
  • Jul 5，2022
  • What is Lithium diisopropylamide?
  • Lithium diisopropylamide (commonly abbreviated LDA) is a chemical compound with the molecular formula [(CH3)2CH]2NLi. It is us....
  • Feb 22，2021

4111-54-0(Lithium diisopropylamide)Related Search:

Diisopropylamine Lithium amide N,N-Diisopropylethylamine Lithium oxide Lithium bis(trimethylsilyl)amide
DIISOPROPYL ZINC 1.0M SOLUTION IN TOLU& N-Methyl-2-pyrrolidone N,N'-Diisopropylcarbodiimide Lithium chloride Lithium
LITHIUM DIMETHYLAMIDE LITHIUM DIETHYLAMIDE Isopropylamine Lithium diisopropylamide mono(tetrahydrofuran) Lithium diisopropylamide mono(tetrahydrofuran) complex solution
LITHIUM TETRAMETHYLPIPERIDIDE LITHIUM DICYCLOHEXYLAMIDE Lithium diisopropylamide
chevron_left

1of4

chevron_right
LITHIUM DIISOPROPYLAMIDE THF COMPLEX LITHIUM DIISOPROPYLAMIDE LDA THF COMPLEX DIISOPROPYLAMINOLITHIUM Lithium diisopropylamide solution n-(1-methylethyl)-2-propanaminlithiumsalt Lithium diisopropylamide, 2M solution in THF/n-heptane/ethylbenzene LITHIUMDIISOPROPYLAMIDE,2MSOLUTIONINTETRAHYDROFURAN/HEPTANE/ETHYLBENZENE Lithium dlisopropylamide LITHIUM DIISOPROPYLAMIDE, 10 WT. % SOLUT ION IN MINERAL OIL LITHIUM DIISOPROPYLAMIDE, 2.0M SOLUTION IN HEPTANE/THF/ETHYLBENZENE LITHIUM DIISOPROPYLAMIDE, 1.8M SOLUTION IN THF/HEPTANE/ETHYLBENZENE LITHIUM DIISOPROPYLAMIDE, 10 WT. % SUSPE NSION IN HEXANES Lithium diisopropylamide solution, ~2 M in THF/heptane/ethylbenzene LITHIUM DIISOPROPYLAMIDE, 2M SOLUTION IN THF/HEPTANE LITHIUM DIISOPROPYLAMIDE, 2M SOLUTION IN THF/N-HEPTANE LITHIUM DIISOPROPYLAMIDE, 2.0M SOLUTION IN THF/ETHYLBENZENE Lithium Diisopropylamide (25% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 2mol/L) LithiuM diisopropylaMide solution 2.0 M in THF LithiuM diisopropylaMid LithiuM diisopropylaMide solution 1.0 M in THF/hexanes LithiuM diisopropylaMide solution 1.8 M in THF/heptane/ethylbenzene LithiuM diisopropylaMide solution 2.0 M in THF/heptane/ethylbenzene LithiuM diisopropylaMide, 2.0 M solution in THF/n-heptane ethylbenzene, SpcSeal LithiuM diisopropylaMide, 2.0 M solution in THF/n-heptane/ethylbenzene (26%/28%/13%) LithiuM diisopropylaMide, 2.0 M solution in THF/n-heptane/ethylbenzene (26%/28%/13%), J&KSeal Lithium diisopropylamide, 2M in THF/heptane/ethylbenzene LithiuM diisopropylaMide solution 2.0 M in THF/heptane 2-Propanamine,N-(1-methylethyl)-,lithiumsalt Lithium diisopropylamide2M sol. in THF/n-heptane/ethylbenzeneAcroSeal§3 Diisopropyllithioamine N-Lithiobis(1-methylethyl)amine N-Lithio-N,N-diisopropylamine Lithium diisopropylamide,2M sol. in THF/n-heptane/ethylbenzene Lithium diisopropylamide, 2M sol. in THF/n-heptane/ethylbenzene, AcroSeal? Lithium diidopropylamide 2.0 M Lithium Diisopropylamide,2M solution in THF Lithium diisopropylamide [2M in THF/n-heptane/ethylbenzene] Lithium diisopropylamide solution,LDA Lithium diisopropyla iisopropylamide LithiuM DiisopropylaMide (LDA), 2M in THF/Heptane/Ethylbenzene LithiuM DiisopropylaMide (LDA), 2M in THF LithiuM DiisopropylaMide (ca. 20% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 1.5Mol/L) LithiuM diisopropylaMide, 2M in THF LithiuM DiisopropylaMide (LDA), 2M in THF/Hexane Lithium diisopropylamide, 2.0 M solution in THF/n-heptane/ethylbenzene (22%/35%/14%), J&KSeal DIIS Lithiodiisopropylamine Lithium diisopropylamide, 2.0 M solution in THF/n-heptane/ethylbenzene (22%/35%/14%), J& Kseal,reagent grade Lithium diisopropylamide ISO 9001：2015 REACH Lithiodiisopropylamide DISCONTINUED Lithium Diisopropylamide 2.0M In THF / 0.7M In MTBE Lithium dilsopropylamide LITHIUM DIISOPROPYLAMINE LDA lithium diisopropylamide (LDA)