ChemicalBook > Product Catalog >Organic Chemistry >Organometallic compounds >Organolithium >Lithium bis(trimethylsilyl)amide
Lithium bis(trimethylsilyl)amide
- CAS No.
- 4039-32-1
- Chemical Name:
- Lithium bis(trimethylsilyl)amide
- Synonyms
- LIHMDS;LHMDS;LITHIUM HEXAMETHYLDISILAZANE;LITHIUM HEXAMETHYLDISILAZIDE;Lithium bis(trimethylsilyl)amide solution;HMDS Li;LiHMDS（1M）;N-LITHIOHEXAMETHYLDISILAZANE;1,1,1,3,3,3-HEXAMETHYLDISILAZAN LITHIUMSALZ;1,1,1,3,3,3-HEXAMETHYLDISILAZANE LITHIUM SALT
- CBNumber:
- CB2202677
- Molecular Formula:
- C6H18LiNSi2
- Molecular Weight:
- 167.33
- MOL File:
- 4039-32-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/15 16:24:08
| Melting point | 73°C |
|---|---|
| Boiling point | 55-56 °C |
| Density | 0.860 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 48 °F |
| storage temp. | Store below +30°C. |
| solubility | hydrolysis |
| form | Powder |
| color | White |
| Specific Gravity | 0.716 |
| Water Solubility | hydrolysis |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 3567910 |
| Exposure limits |
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin) OSHA: TWA 200 ppm(590 mg/m3) NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| InChIKey | YNESATAKKCNGOF-UHFFFAOYSA-N |
| CAS DataBase Reference | 4039-32-1(CAS DataBase Reference) |
| EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H251-H314 | |||||||||
| Precautionary statements | P210-P235-P260-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | F,C,N | |||||||||
| Risk Statements | 11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19 | |||||||||
| Safety Statements | 9-16-26-29-33-36/37/39-45-61-62-57-43 | |||||||||
| RIDADR | UN 2925 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
Lithium bis(trimethylsilyl)amide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 775053 | Lithium bis(trimethylsilyl)amide solution 0.5?M in 2-methyltetrahydrofuran | 4039-32-1 | 4X25ML | ₹5054 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 775053 | Lithium bis(trimethylsilyl)amide solution 0.5?M in 2-methyltetrahydrofuran | 4039-32-1 | 100ML | ₹7461.3 | 2022-06-14 | Buy |
| Sigma-Aldrich | 775053 | Lithium bis(trimethylsilyl)amide solution 0.5?M in 2-methyltetrahydrofuran | 4039-32-1 | 800ML | ₹21067.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 775053 | Lithium bis(trimethylsilyl)amide solution 0.5?M in 2-methyltetrahydrofuran | 4039-32-1 | 800ML | ₹21067.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 771864 | Lithium bis(trimethylsilyl)amide solution 0.5?M in toluene | 4039-32-1 | 800ML | ₹32052.83 | 2022-06-14 | Buy |
Lithium bis(trimethylsilyl)amide Chemical Properties,Uses,Production
Chemical Properties
light yellow to yellow crystalline powder
Physical properties
distillable low-melting solid; mp 70–72 °C, bp 115 °C/1mmHg. LHMDS is a cyclic trimer in the solid state,3 whereas in benzene solution it exists in a monomer–dimer equilibrium. LHMDS exists as a tetramer-dimer mixture in hydrocarbons and as a dimer-monomer mixture in THF and ether. Treatment of LHMDS with trialkylamines increases the monomer concentration, whereas the use of diamines affords exclusively the corresponding chelated monomer. LHMDS is less soluble, less basic, more stable, and much less sensitive to air compared to lithium diisopropylamide. pKa 29.5 (THF, 27 °C).
Uses
Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.
Preparation
It is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.
General Description
This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention.
Lithium bis(trimethylsilyl)amide Preparation Products And Raw materials
Raw materials
Preparation Products
chevron_left
1of2
chevron_right
Global( 466)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Almas Life Sciences | +919441456585 | Hyderabad, India | 54 | 58 | Inquiry |
| JLS Laboratories Pvt Limited | +91 8790545679 | Hyderabad, India | 62 | 58 | Inquiry |
| VASISTA LIFE SCIENCES PRIVATE LIMITED | +91-04029554774 +91-9010855544 | Hyderabad, India | 153 | 58 | Inquiry |
| Oceanic Pharmachem Pvt Ltd | +91-91-2242128600 +91-2242128600 | Maharashtra, India | 33 | 58 | Inquiry |
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 337 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Ortin Laboratories Limited | +91-9241566560 +91-9241566560 | Hyderabad, India | 31 | 58 | Inquiry |
| Suparna Chemicals Ltd | +91-2222027446 +91-9820623254 | Maharashtra, India | 19 | 58 | Inquiry |
| Organo Metallics | +91-9391016448 +91-9705345345 | Telangana, India | 32 | 58 | Inquiry |
| FMC India Private Limited | Karnataka, India | 16 | 58 | Inquiry |
Related articles
- What is Lithium bis(trimethylsilyl)amide?
- Lithium bis(trimethylsilyl)amide is a non-nucleophilic strong Br?nsted base, which is generally soluble in most of the nonpola....
- Apr 8，2021
4039-32-1(Lithium bis(trimethylsilyl)amide)Related Search:
HEXAMETHYLDISILAZANE LITHIUM SALT
LITHIUM-BIS-(TRIMETHYLSILYL)-AMID
LITHIUM BIS(TRIMETHYLSILYL)AMIDE
Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal bottles
Lithium bis(trimethylsilyl)amide, 1.0m solution in methyl tert-butyl ether
Lithium bis(trimethylsilyl)amide1.0M sol. in methyl tert-butyl etherAcroSeal§3
Lithium bis(trimethylsilyl)amide1M solution in THF/EthylbenzeneAcroSeal§3
Lithium bis(trimethylsilyl)amide0.9M solution in methylcyclohexaneAcroSeal§3
(Lithioimino)bis(trimethylsilane)
[Di(trimethylsilyl)amino] lithium
2-Lithio-1,1,1,3,3,3-hexamethylpropanedisilazane
2-Lithiohexamethylpropanedisilazane
Lithioiminobis(trimethylsilane)
N-Lithio-N-(trimethylsilyl)-α,α,α-trimethylsilanamine
Lithium Hexamethyldisilazide,LiHMDS
1,1,1-trimethyl-n-(trimethylsilyl)-silanaminlithiumsalt
lithium-bis-(trimethylsilyl)-amide(30%inthf)
Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene
Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSealTM bottles
Lithium Hexamethyldisilazide (29% in Tetrahydrofuran, ca. 1.6mol/L)
Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t bottles
Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t
Lithium bis(trimethylsilyl)amide,1.3M solution in toluene/ethylbenzene
Lithium bis(trimethylsilyl)amide, 1.3M solution in THF
Lithium bis(trimethylsilyl)amide,1.3M solution in hexanes/ethylbenzene
LithiuM Bis(triMethylsilyl)aMide (ca. 26% in Tetrahydrofuran, ca. 1.3Mol/L)
LithiuM bis(triMethylsilyl)aMide, stab. with hexane
Hexamethyldisilazane Lithium Salt
LiHMDS
Lithium Hexamethyldisilazide
LithiuM bis(triMethylsilyl)aMide, 15% in 2-MeTHF/Ethylbenzene, AcroSeal
LITHIUM HEXAMETHYLDISILAZIDE, 1.25M in tetrahydrofuran
LithiuM bis(triMethylsilyl) aMide, titr 95%
LithiuM bis(triMethylsilyl)aMide solution
1.0 M in THF
LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF
LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, J&KSeal
LithiuM bis(triMethylsilyl)aMide solution 1 M in toluene
LithiuM bis(triMethylsilyl)aMide solution 1.0 M in hexanes
LithiuM bis(triMethylsilyl)aMide, 0.5 M solution in toluene, SpcSeal
Double triMethyl silyl aMino lithiuM
LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, SpcSeal
LithiuM bis(triMethylsilyl)aMide, 1.0M solution in Methyl tert-butyl ether, SpcSeal
Lithium bis(trimethylsilyl)amide, 1.0M sol. in methyl tert-butyl ether
Lithium bis(trimethylsilyl)amide, 1M solution in THF/Ethylbenzene
Hexamethyldisilazanelithiumsalt24%THF
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt
lithium bis(trimethylsilyl)amide, 0.9-1.1m in hexane, packaged under argon in resealable chemseal
llthium(hexamethyldisilazane)
Lithium bis(trimethylsilyl) amide, titr 95 %
Lithium Bis(trimethylsilyl)amide,1.0M in THF
Lithium bis(trimethyly silyl)acide
LITHIUM BIS(TRIMETHYLSILYL)AMIDE, 1M IN TETRAHYDROFURAN
LITHIUM BIS(TRIMETHYLSILYL)AMIDE, 1M IN HEXANE
LITHIUM BIS(TRIMETHYLSILYL)AMIDE: 20% (CA. 1.06M) SOLUTION IN THF
LITHIUM HMDS 30% IN THF
LITHIUM BIS(TRIMETHYLSILYL)AMIDE, 1.0M &
LITHIUM BIS(TRIMETHYLSILYL)AMIDE, 1 M &
LITHIUM BIS(TRIMETHYLSILYL)AMIDE SOL., ~ 1 M IN HEXANE
LITHIUM BIS(TRIMETHYLSILYL)AMIDE 1 M SOLUTION IN TERT-BUTYL METHYL ETHER
LITHIUM BIS(TRIMETHYLSILYL)AMIDE SOLUTIO N,~1 M IN THF