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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >Geldanamycin

Geldanamycin

Geldanamycin Structure
  • ₹8800 - ₹86123.7
  • Product name: Geldanamycin
  • CAS: 30562-34-6
  • MF: C29H40N2O9
  • MW: 560.64
  • EINECS:999-999-2
  • MDL Number:MFCD00274570
  • Synonyms:CP-122634;9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate;NSC 212518;GELDANAMYCIN FROM STRE;GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus;GeldanaMycin froM StreptoMyces hygroscopi;2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate;Geldanamycin [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)
  • SRL

Package

  • 1MG
  • 5mg
  • 10MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1278
  • Product descriptionGeldanamycin Ready Made Solution 1?mg/mL, from Streptomyces hygroscopicus
  • Packaging1ML
  • Price₹17383.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG3381
  • Product descriptionGeldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder
  • Packaging1MG
  • Price₹86123.7
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberG0334
  • Product descriptionGeldanamycin
  • Packaging10MG
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number23813
  • Product descriptionGeldanamycin (GLD), 98%
  • Packaging5mg
  • Price₹65210
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1278 Geldanamycin Ready Made Solution 1?mg/mL, from Streptomyces hygroscopicus 1ML ₹17383.1 2022-06-14 Buy
Sigma-Aldrich(India) G3381 Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder 1MG ₹86123.7 2022-06-14 Buy
TCI Chemicals (India) G0334 Geldanamycin 10MG ₹8800 2022-05-26 Buy
SRL 23813 Geldanamycin (GLD), 98% 5mg ₹65210 2022-05-26 Buy

Properties

Melting point :255 °C
Boiling point :627.87°C (rough estimate)
Density :1.2443 (rough estimate)
refractive index :1.5800 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :8.42±0.70(Predicted)
color :yellow to orange
biological source :Streptomyces hygroscopicus
λmax :305nm(MeOH)(lit.)
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
CAS DataBase Reference :30562-34-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Precautionary statements:
P403+P235 Store in a well-ventilated place. Keep cool.

Description

Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding. It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function. Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. A.J Chemicals Sisco Research Laboratories Pvt. Ltd. Triveni chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Anand Agencies Maas Pharma Chemicals Pharma Affiliates Innovative Synthetic Molecules Biopharmacule Speciality Chemicals P Ltd (India)