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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Tinib Antineoplastic drugs >17-AAG

17-AAG

17-AAG Structure
  • ₹18880 - ₹32407
  • Product name: 17-AAG
  • CAS: 75747-14-7
  • MF: C31H43N3O8
  • MW: 585.69
  • EINECS:
  • MDL Number:MFCD04973892
  • Synonyms:GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-;CP 127374;ALLYLAMINOGELDANAMYCIN;NSC-330507;17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN;17-ALLYLAMINOGELDANAMYCIN
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • ALFA India
  • Sigma-Aldrich(India)

Package

  • 500μG
  • 25mg
  • 100mg
  • 200mg
  • ManufacturerALFA India
  • Product numberALF-J66960-MB
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging25mg
  • Price₹18880
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J66960-MC
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging100mg
  • Price₹27694
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J66960-EX3
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging200mg
  • Price₹32407
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number100068
  • Product description17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.
  • Packaging500μG
  • Price₹31190
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA8476
  • Product description17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid
  • Packaging500μG
  • Price₹31284.25
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-J66960-MB 17-(Allylamino)-17-demethoxygeldanamycin, 99% 25mg ₹18880 2022-05-26 Buy
ALFA India ALF-J66960-MC 17-(Allylamino)-17-demethoxygeldanamycin, 99% 100mg ₹27694 2022-05-26 Buy
ALFA India ALF-J66960-EX3 17-(Allylamino)-17-demethoxygeldanamycin, 99% 200mg ₹32407 2022-05-26 Buy
Sigma-Aldrich(India) 100068 17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus. 500μG ₹31190 2022-06-14 Buy
Sigma-Aldrich(India) A8476 17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid 500μG ₹31284.25 2022-06-14 Buy

Properties

Melting point :201-203°C
Boiling point :797.8±60.0 °C(Predicted)
Density :1.21
RTECS :LX8932000
Flash point :>110°(230°F)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :8.62±0.70(Predicted)
color :Purple or dark red
Water Solubility :Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference :75747-14-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

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