17-AAG
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- ₹18880 - ₹32407
- Product name: 17-AAG
- CAS: 75747-14-7
- MF: C31H43N3O8
- MW: 585.69
- EINECS:
- MDL Number:MFCD04973892
- Synonyms:GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-;CP 127374;ALLYLAMINOGELDANAMYCIN;NSC-330507;17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN;17-ALLYLAMINOGELDANAMYCIN
5 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
- ALFA India
Package
- 25mg
- 100mg
- 200mg
- 500μG
- ManufacturerSigma-Aldrich(India)
- Product numberA8476
- Product description17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid
- Packaging500μG
- Price₹31284.25
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number100068
- Product description17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.
- Packaging500μG
- Price₹31190
- Updated2022-06-14
- Buy
- ManufacturerALFA India
- Product numberALF-J66960-EX3
- Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
- Packaging200mg
- Price₹32407
- Updated2022-05-26
- Buy
- ManufacturerALFA India
- Product numberALF-J66960-MC
- Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
- Packaging100mg
- Price₹27694
- Updated2022-05-26
- Buy
- ManufacturerALFA India
- Product numberALF-J66960-MB
- Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
- Packaging25mg
- Price₹18880
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8476 | 17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid | 500μG | ₹31284.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 100068 | 17-AAG - CAS 75747-14-7 - Calbiochem A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus. | 500μG | ₹31190 | 2022-06-14 | Buy |
| ALFA India | ALF-J66960-EX3 | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 200mg | ₹32407 | 2022-05-26 | Buy |
| ALFA India | ALF-J66960-MC | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 100mg | ₹27694 | 2022-05-26 | Buy |
| ALFA India | ALF-J66960-MB | 17-(Allylamino)-17-demethoxygeldanamycin, 99% | 25mg | ₹18880 | 2022-05-26 | Buy |
Properties
Melting point :201-203°C
Boiling point :797.8±60.0 °C(Predicted)
Density :1.21
RTECS :LX8932000
Flash point :>110°(230°F)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :8.62±0.70(Predicted)
color :Purple or dark red
Water Solubility :Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :AYUNIORJHRXIBJ-HTLBVUBBSA-N
SMILES :C12C(=O)C(=CC(=O)C=1NCC=C)NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2 |t:17,19,30|
CAS DataBase Reference :75747-14-7
Boiling point :797.8±60.0 °C(Predicted)
Density :1.21
RTECS :LX8932000
Flash point :>110°(230°F)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :8.62±0.70(Predicted)
color :Purple or dark red
Water Solubility :Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :AYUNIORJHRXIBJ-HTLBVUBBSA-N
SMILES :C12C(=O)C(=CC(=O)C=1NCC=C)NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2 |t:17,19,30|
CAS DataBase Reference :75747-14-7
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).More related product prices
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