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Alvespimycin

Alvespimycin Structure
CAS No.
467214-20-6
Chemical Name:
Alvespimycin
Synonyms
17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;DMAG-d6;CS-2382;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6
CBNumber:
CB7972636
Molecular Formula:
C32H48N4O8
Molecular Weight:
616.75
MOL File:
467214-20-6.mol
MSDS File:
SDS
Modify Date:
2024/11/19 20:33:22
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Alvespimycin Properties

Melting point >270°C (dec.)
Boiling point 810.5±65.0 °C(Predicted)
Density 1.20
storage temp. Desiccate at -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.48±0.70(Predicted)
color Very Dark Purple

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  29419090

Alvespimycin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ottokemi D 8505 17-DMAG ≥98% 467214-20-6 1mg ₹38709 2022-05-26 Buy
ottokemi D 8505 17-DMAG ≥98% 467214-20-6 5mg ₹5288674 2022-05-26 Buy
Product number Packaging Price Buy
D 8505 1mg ₹38709 Buy
D 8505 5mg ₹5288674 Buy

Alvespimycin Chemical Properties,Uses,Production

Description

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

Chemical Properties

Solid

Uses

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Definition

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.

Biological Activity

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Alvespimycin Preparation Products And Raw materials

Raw materials

Preparation Products

Alvespimycin Suppliers

Global( 124)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5870 58 Inquiry
Shaanxi Haibo Biotechnology Co., Ltd +undefined18602966907 China 997 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32190 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9304 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 +8617705817739 China 52849 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Supplier Advantage
Otto Chemie Pvt. Ltd. 58
Shaanxi Haibo Biotechnology Co., Ltd 58
career henan chemical co 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Baoji Guokang Bio-Technology Co., Ltd. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

467214-20-6(Alvespimycin)Related Search:

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17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG 17-DMAGhydrochloride Alvespimycin 17-DMAG (Alvespimycin) Unii-001L2fe0m3 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6 17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride DMAG Hydrochloride NSC 707545 Hydrochloride 17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin 17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin 17-DMAG-d6 17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin AlvespiMycin-d6 DMAG-d6 NSC 707545-d6 AlvespiMycin freebase In-house Standard 17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin) AlvespiMycin(17-DMAG) 17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin (150270-08-9) alvespimycin CS-2382 17-DMAG;KOS-1022;NSC-707545 Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]- 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin 17-DMAG 17-DMAG HCI spiromycin Dimethylaminoethylamino-17-demethoxygeldanamycin, 17- 467214-20-6 C32H48N4O8HCl Isotope Labelled Compounds Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals