Spiramycin
- CAS No.
- 8025-81-8
- Chemical Name:
- Spiramycin
- Synonyms
- LEUCOMYCIN;espiramicin;Spiramycine;Spiramycin Ep;KITASAMYCIN BASE;5337r.p.;r.p.5337;rovamycin;nsc-64393;provamycin
- CBNumber:
- CB0396400
- Molecular Formula:
- C43H74N2O14
- Molecular Weight:
- 843.05
- MOL File:
- 8025-81-8.mol
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | 126-128 °C |
|---|---|
| Boiling point | 914℃ |
| alpha | D20 -80° (methanol) |
| refractive index | 81 ° (C=2, 10% AcOH) |
| Flash point | >110°(230°F) |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL, clear to slightly hazy, light-yellow |
| form | powder |
| color | white to light yellow |
| optical activity | [α]/D -85 to -80° in water (Specific rotation (dry basis)) |
| Water Solubility | Soluble in methanol. Slightly soluble in water |
| Merck | 14,8752 |
| CAS DataBase Reference | 8025-81-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303 | |||||||||
| Precautionary statements | P270-P301+P312-P403-P501c | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | WG9400000 | |||||||||
| F | 10 | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 9400 orally; 1000 s.c.; 170 i.v. (Sous) | |||||||||
| NFPA 704 |
|
Spiramycin price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9132 | Spiramycin | 8025-81-8 | 1G | ₹8757.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9132 | Spiramycin | 8025-81-8 | 5G | ₹26542.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46745 | Spiramycin from Streptomyces sp. VETRANAL?, analytical standard, mixture of isomers | 8025-81-8 | 100MG | ₹5618.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0575 | Spiramycin | 8025-81-8 | 5G | ₹7700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0575 | Spiramycin | 8025-81-8 | 25G | ₹9800 | 2022-05-26 | Buy |
Spiramycin Chemical Properties,Uses,Production
Description
Spiramycin was found in the culture broth of Streptomyces ambofaciens by Rhone Poulenc in 1954 and its acetate was synthesized by Kyowa Hakko Kogyo Co. in 1965. This antibiotic consists of three closely related macrolide components, I, II, and III, whose ratio is 2 : 1 : 1. Spiramycin shows almost the same antimicrobial spectrum and activity as the other macrolides, but its acetate, acetylspiramycin, has much better pharmacokinetic properties and activity in vivo.
Chemical Properties
An antibiotic substance.
Uses
Spiramycin I (foromacidin A) is the major analogue of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in that they contain two basic sugars. Spiramycin complex has been used in both human and animal health but its use has not been widespread.
Antimicrobial activity
Enterobacteriaceae are resistant. Spiramycin is also active against anaerobic species: Actinomyces israelii (MIC 2–4 mg/L), Cl. perfringens (MIC 2–8 mg/L) and Bacteroides spp. (MIC 4–14 mg/L). It is also active against Tox. gondii.
Hazard
Poison; moderately toxic; teratogen; muta- gen; can cause hypermotility, diarrhea, nausea, or vomiting.
Pharmaceutical Applications
A fermentation product of Streptomyces ambofaciens, composed of several closely related compounds. Spiramycin 1 is the major component (c. 63%); spiramycins 2 and 3 are the acetate and monopropionate esters, respectively. It is available for oral administration and as spiramycin adipate for intravenous infusion. Spiramycins are relatively stable in acid conditions. A derivative, acetylspiramycin, is available in Japan.
Pharmacokinetics
Oral absorption: Variable
Cmax 1 g oral： 2.8 mg/L after 2 h
Plasma half-life：4–8h
Volume of distribution ：383 L
Plasma protein binding ：15%
In healthy volunteers given 2 g orally followed by 1 g every 6 h, peak plasma levels were 1.0–6.7 mg/L. After 1 g orally the AUC was 10.8 mg.h/L, with an apparent elimination halflife of 2.8 h. It is widely distributed in the tissues. It does not reach the CSF. Levels 12 h after a dose of 1 g were 0.25 mg/L in serum, 5.3 mg/L in bone and 6.9 mg/L in pus. Levels of 10.6 mg/L have been found 4 h after dosing in saliva, and concentrations at least equal to those in the serum are seen in bronchial secretions. A concentration of 27 mg/g was found in prostate tissues after repeated dosage. Only 5–15% is recovered from the urine. Most is metabolized, but significant quantities are eliminated via the bile, in which concentrations up to 40 times those in the serum may be found.
Side effects
Spiramycin is generally well tolerated, the most common adverse reactions being gastrointestinal disturbances, notably abdominal pain, nausea and vomiting, rashes and sensitization following contact.
Spiramycin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Chandra Prabhu Pharma Services | 08048372381Ext 506 | Maharashtra, India | 19 | 58 | Inquiry |
| Harshada Corporation | 08048372248Ext 946 | Mumbai, India | 3 | 58 | Inquiry |
| Add Biotec | 91-22-26731400 | Maharashtra, India | 49 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Triveni chemicals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Chandra Prabhu Pharma Services | 58 |
| Harshada Corporation | 58 |
| Add Biotec | 58 |
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