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SB216763

CAS No.: 280744-09-4

Chemical Name:: SB216763

Synonyms: CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE

CBNumber:: CB9493416

Molecular Formula:: C19H12Cl2N2O2

Molecular Weight:: 371.22

MOL File:: 280744-09-4.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

SB216763 Properties

Melting point	287-288.6 °C(lit.)
Boiling point	598.1±50.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 20 mg/mL, soluble
form	Orange solid
pka	7.27±0.60(Predicted)
color	orange
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29339900

NFPA 704

	0
2		0

SB216763 price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S3442	SB 216763 >98% (HPLC)	280744-09-4	5MG	₹16475.65	2022-06-14	Buy
Sigma-Aldrich(India)	S3442	SB 216763 >98% (HPLC)	280744-09-4	25MG	₹63542.75	2022-06-14	Buy
Sigma-Aldrich(India)	361566	GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem	280744-09-4	10MG	₹17860	2022-06-14	Buy
TCI Chemicals (India)	B5716	SB 216763	280744-09-4	10MG	₹6800	2022-05-26	Buy
TCI Chemicals (India)	B5716	SB 216763	280744-09-4	50MG	₹14800	2022-05-26	Buy

Product number	Packaging	Price	Buy
S3442	5MG	₹16475.65	Buy
S3442	25MG	₹63542.75	Buy
361566	10MG	₹17860	Buy
B5716	10MG	₹6800	Buy
B5716	50MG	₹14800	Buy

SB216763 Chemical Properties,Uses,Production

Uses

SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Biochem/physiol Actions

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

SB216763 Preparation Products And Raw materials

Raw materials

Preparation Products

SB216763 Suppliers

Global( 178)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

SB216763 Spectrum

SB216763(280744-09-4)¹HNMR

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SB 216763 3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE 3-(2,4-Dichlorophenyl)-4-... 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione SB-216763(SB 216763) GSK-3 Inhibitor IV, SB-216763 CS-332 GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)- SB216763 USP/EP/BP 3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide 280744-09-4 C19H12Cl2N2O2 C19H12N2O2Cl2 C19Cl2H12N2O2 Cell Signaling and Neuroscience Cell Biology BioChemical Glycogen Synthase Kinase 3 (GSK3) Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Inhibitors Akt mTOR PI3K Protein Kinase Signalling