ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >GPCR & G Protein >CXCR antagonist >SB 225002

SB 225002

CAS No.: 182498-32-4

Chemical Name:: SB 225002

Synonyms: SB 225002;SB-225002;SB 225002;SB 225002 USP/EP/BP;SB225002 182498-32-4;SB 225002 - CAS 182498-32-4 - Calbiochem;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA;N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-

CBNumber:: CB1455331

Molecular Formula:: C13H10BrN3O4

Molecular Weight:: 352.14

MOL File:: 182498-32-4.mol

Modify Date:: 2023/7/12 16:39:50

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SB 225002 Properties

Boiling point	401.6±45.0 °C(Predicted)
Density	1.793±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	Soluble to 100mM in DMSO and to 50mM in ethanol
form	Yellow solid
pka	5.29±0.10(Predicted)
color	white to beige
Sensitive	Moisture Sensitive
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	MQBZVUNNWUIPMK-UHFFFAOYSA-N
CAS DataBase Reference	182498-32-4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

HS Code

2921490090

NFPA 704

	0
2		0

SB 225002 price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0716	SB225002 ≥98% (HPLC)	182498-32-4	5MG	₹11387.9	2022-06-14	Buy
Sigma-Aldrich(India)	SML0716	SB225002 ≥98% (HPLC)	182498-32-4	25MG	₹46374.3	2022-06-14	Buy
Sigma-Aldrich(India)	559405	SB 225002 - CAS 182498-32-4 - Calbiochem A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC?? = 22 nM for the inhibition of 12?I-IL-8 binding	182498-32-4	1MG	₹13710	2022-06-14	Buy
TCI Chemicals (India)	B6055	SB 225002	182498-32-4	10MG	₹7200	2022-05-26	Buy
TCI Chemicals (India)	B6055	SB 225002	182498-32-4	50MG	₹22500	2022-05-26	Buy

Product number	Packaging	Price	Buy
SML0716	5MG	₹11387.9	Buy
SML0716	25MG	₹46374.3	Buy
559405	1MG	₹13710	Buy
B6055	10MG	₹7200	Buy
B6055	50MG	₹22500	Buy

SB 225002 Chemical Properties,Uses,Production

Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC₅₀ value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC₅₀ = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC₅₀ = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.

Uses

SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.

Biological Activity

Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

SB 225002 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 225002 Suppliers

Global( 129)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
Accela ChemBio Inc.	+1-858-6993322	United States	19479	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

SB 225002 Spectrum

SB 225002(182498-32-4)¹HNMR

182498-32-4(SB 225002)Related Search:

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SB 225002 N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea SB 225002 - CAS 182498-32-4 - Calbiochem SB-225002;SB 225002 Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)- SB 225002 USP/EP/BP SB225002 182498-32-4 182498-32-4 18298-32-4 Inhibitors A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2. Antineoplastic