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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >p38 MAPK inhibitor >SB 203580

SB 203580

SB 203580 Structure
CAS No.
152121-47-6
Chemical Name:
SB 203580
Synonyms
CS-42;SB SB;SB203850;PB 203580;RWJ 64809;SB 203580;SB 2035850;Adezmapimod;SB 203580, >=98%;SB203580;SB 203580
CBNumber:
CB1680333
Molecular Formula:
C21H16FN3OS
Molecular Weight:
377.43
MOL File:
152121-47-6.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

SB 203580 Properties

Melting point 144-146
Boiling point 615.6±55.0 °C(Predicted)
Density 1.4
storage temp. -20°C
solubility DMSO: 50 mg/mL
form solid
pka 9.60±0.10(Predicted)
color white to off-white
Stability -200C
InChIKey CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS DataBase Reference 152121-47-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P501
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  3
HS Code  29333990
NFPA 704
0
3 0

SB 203580 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 559389 SB 203580 - CAS 152121-47-6 - Calbiochem SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC?? 152121-47-6 1MG ₹20450 2022-06-14 Buy
Sigma-Aldrich(India) S8307 SB 203580 solid, ≥98% (HPLC) 152121-47-6 1MG ₹24334.6 2022-06-14 Buy
Sigma-Aldrich(India) 559389 SB 203580 - CAS 152121-47-6 - Calbiochem SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC?? 152121-47-6 5MG ₹34100 2022-06-14 Buy
Sigma-Aldrich(India) 559389 SB 203580 - CAS 152121-47-6 - Calbiochem SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC?? 152121-47-6 10MG ₹37350 2022-06-14 Buy
TCI Chemicals (India) F0864 SB 203580 152121-47-6 25MG ₹6500 2022-05-26 Buy
Product number Packaging Price Buy
559389 1MG ₹20450 Buy
S8307 1MG ₹24334.6 Buy
559389 5MG ₹34100 Buy
559389 10MG ₹37350 Buy
F0864 25MG ₹6500 Buy

SB 203580 Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18

Definition

ChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.

General Description

Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 kinase (IC50 = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 μM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.

Biological Activity

Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

SB 203580 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 203580 Suppliers

Global( 226)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21677 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
Otto Chemie Pvt. Ltd. 58
Capot Chemical Co.,Ltd. 60
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58

SB 203580 Spectrum

SB 203580(152121-47-6)1HNMR

152121-47-6(SB 203580)Related Search:

SB 203580 (hydrochloride) 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Ispinesib U0126-EtOH MK-2206 2HCl
1,9-Pyrazoloanthrone PD 98059 SCH772984 LY 294002 HYDROCHLORIDE SB242235
SB-705498 4'-CHLORO-3-METHOXYCINNAMANILIDE 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline SB1317 SB 269970 HYDROCHLORIDE
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 431542 SB 202190
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SB 203580 HYDROCHLORIDE SB 2035850 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL 4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine PB 203580 Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- 4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole SB 203580, >=98% 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB 203580 SB 203580 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole RWJ 64809 RWJ 64809; PB 203580 SB 203580 MAPK inhibitor (SB 203580) SB203580(RWJ 64809) SB 203580 - CAS 152121-47-6 - Calbiochem SB203580;SB 203580 SB203580 (RWJ 64809, PB 203580) CS-42 RWJ 64809;PB 203580;SB203580;SB-203580 SB SB SB 203580USP/EP/BP SB 203580 hydrochlor Adezmapimod SB 203580, ≥98% (HPLC) SB203850 Adezmapimod (SB203580 Inhibitor,SB-203580,PKBα,RWJ64809,inhibit,SAPK2a,GSK3β,Mitophagy,SB 203580,p38 MAPK,Mitochondrial Autophagy,Autophagy,LCK,RWJ-64809,Adezmapimod,SAPK2b,ATP-competitive 152121-47-6 C21H16FN3OSHCl C21H16FN3OS Cell Signaling and Neuroscience Cell Biology BioChemical Kinase/Phosphatase Biology MAPK-Activated Protein Kinase (MAPKAP Kinase) Serine/Threonine Kinase Inhibitors Inhibitors Selective inhibitor of p38 mitogen-activated protein kinase. inhibitor Signalling Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase pharmacetical